Xpo1 exportin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Xpo1provided by MGI
Official Full Name: exportin 1provided by MGI
Primary source: MGI:MGI:2144013
See related: Ensembl:ENSMUSG00000020290 AllianceGenome:MGI:2144013
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Crm1; Exp1
Summary: Enables nuclear export signal receptor activity. Involved in mRNA export from nucleus and protein export from nucleus. Acts upstream of or within several processes, including protein localization to nucleus; regulation of centrosome duplication; and regulation of protein export from nucleus. Located in nucleus. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 31.7), limb E14.5 (RPKM 25.4) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A3.2; 11 14.28 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (23205768..23248250)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (23255909..23297597)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differential impact of exportin-1-mediated nuclear export of RNAs on the RNA content of extracellular vesicle subpopulations.
Title: Differential impact of exportin-1-mediated nuclear export of RNAs on the RNA content of extracellular vesicle subpopulations.
Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML.
Title: Prolonged XPO1 inhibition is essential for optimal antileukemic activity in NPM1-mutated AML.
Hydrocortisone alleviates sepsis-induced acute kidney injury through HSF-1-mediated transcriptional suppression of XPO1.
Title: Hydrocortisone alleviates sepsis-induced acute kidney injury through HSF-1-mediated transcriptional suppression of XPO1.
Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain.
Title: Enhanced Activity of Exportin-1/CRM1 in Neurons Contributes to Autophagy Dysfunction and Senescent Features in Old Mouse Brain.
Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells.
Title: Gluten-induced RNA methylation changes regulate intestinal inflammation via allele-specific XPO1 translation in epithelial cells.
Inhibition of Autism-Related Crm1 Disrupts Mitosis and Induces Apoptosis of the Cortical Neural Progenitors.
Title: Inhibition of Autism-Related Crm1 Disrupts Mitosis and Induces Apoptosis of the Cortical Neural Progenitors.
Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
Title: Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA.
Title: NXF1 and CRM1 nuclear export pathways orchestrate nuclear export, translation and packaging of murine leukaemia retrovirus unspliced RNA.
myeloid transformation requires the interaction of XPO1 with SETBP1
Title: Interaction with XPO1 is essential for SETBP1 to induce myeloid transformation.
Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias.
Title: Combinatorial targeting of XPO1 and FLT3 exerts synergistic anti-leukemia effects through induction of differentiation and apoptosis in FLT3-mutated acute myeloid leukemias: from concept to clinical trial.

Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124275 (e-PCR)
- UniSTS:161097

Xpo1 (e-PCR), detects polymorphism
- UniSTS:498285

Xpo1 (e-PCR), detects polymorphism
- UniSTS:507329

NoName (e-PCR)
- UniSTS:236532

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables nuclear export signal receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear export signal receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables nuclear export signal receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nuclear export signal receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in nucleocytoplasmic transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein export from nucleus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein export from nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal small subunit export from nucleus	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in ribosomal subunit export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in ribosome biogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
located_in annulate lamellae	IEA Inferred from Electronic Annotation more info
located_in annulate lamellae	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: exportin-1

Names: chromosome region maintenance 1 protein homolog; exportin 1, CRM1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412406.1 → NP_001399335.1 exportin-1

Status: VALIDATED

Source sequence(s)

AL772359

UniProtKB/Swiss-Prot

Q6P5F9
NM_001412407.1 → NP_001399336.1 exportin-1

Status: VALIDATED

Source sequence(s)

AL772359

Consensus CDS

CCDS24475.1

UniProtKB/Swiss-Prot

Q6P5F9

Related

ENSMUSP00000099933.2, ENSMUST00000102869.8
NM_001412408.1 → NP_001399337.1 exportin-1

Status: VALIDATED

Source sequence(s)

AL772359

UniProtKB/Swiss-Prot

Q6P5F9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

23205768..23248250

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017314209.3 → XP_017169698.1 exportin-1 isoform X3

Conserved Domains (1) summary

COG5101
Location:1 → 913

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]
XM_017314208.3 → XP_017169697.1 exportin-1 isoform X2

Conserved Domains (1) summary

COG5101
Location:10 → 978

CRM1; Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001035226.1: Suppressed sequence

Description

NM_001035226.1: This RefSeq was removed because currently there is insufficient support for the transcript.
NM_134014.3: Suppressed sequence

Description

NM_134014.3: This RefSeq was removed because currently there is insufficient support for the transcript.