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    Sh3yl1 Sh3 domain YSC-like 1 [ Mus musculus (house mouse) ]

    Gene ID: 24057, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Sh3yl1provided by MGI
    Official Full Name
    Sh3 domain YSC-like 1provided by MGI
    Primary source
    MGI:MGI:1346118
    See related
    Ensembl:ENSMUSG00000020669 AllianceGenome:MGI:1346118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ray; YSC84
    Summary
    Predicted to enable phosphatase binding activity and phosphatidylinositol binding activity. Acts upstream of or within phosphatidylinositol biosynthetic process and regulation of ruffle assembly. Predicted to be active in ruffle membrane. Orthologous to human SH3YL1 (SH3 and SYLF domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver E14 (RPKM 10.0), liver E14.5 (RPKM 8.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sh3yl1 in Genome Data Viewer
    Location:
    12 A2; 12 13.01 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (30961622..31010159)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (30911669..30960160)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32320 Neighboring gene ALK and LTK ligand 2 Neighboring gene STARR-seq mESC enhancer starr_31845 Neighboring gene STARR-positive B cell enhancer ABC_E7128 Neighboring gene acid phosphatase 1, soluble Neighboring gene STARR-seq mESC enhancer starr_31846 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene crumbs homolog 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nox4-SH3YL1 complex is involved in diabetic nephropathy. Lee SR, et al. iScience, 2024 Feb 16. PMID 38318360, Free PMC Article
    2. SH3YL1 protein as a novel biomarker for diabetic nephropathy in type 2 diabetes mellitus. Choi GS, et al. Nutr Metab Cardiovasc Dis, 2021 Feb 8. PMID 33223406
    3. LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1. Yoo JY, et al. Cell Rep, 2020 Oct 20. PMID 33086058
    4. A novel mouse gene, Sh3yl1, is expressed in the anagen hair follicle. Aoki N, et al. J Invest Dermatol, 2000 May. PMID 10771491
    5. SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain. Hasegawa J, et al. J Cell Biol, 2011 May 30. PMID 21624956, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1.
      Title: LPS-Induced Acute Kidney Injury Is Mediated by Nox4-SH3YL1.
    2. SH3YL1 protein as a novel biomarker for diabetic nephropathy in type 2 diabetes mellitus.
      Title: SH3YL1 protein as a novel biomarker for diabetic nephropathy in type 2 diabetes mellitus.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118159

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphatidylinositol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of ruffle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SH3 domain-containing YSC84-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289480.1 → NP_001276409.1  SH3 domain-containing YSC84-like protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001276409.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
      Source sequence(s)
      AC160932, BB433755, BC058557, BY086053
      Consensus CDS
      CCDS79110.1
      UniProtKB/Swiss-Prot
      O08641
      Related
      ENSMUSP00000106504.3, ENSMUST00000110880.3
      Conserved Domains (2) summary
      cd11525
      Location:11 → 171
      SYLF_SH3YL1_like; The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins
      cd11841
      Location:247 → 300
      SH3_SH3YL1_like; Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein

    2. NM_013709.5 → NP_038737.1  SH3 domain-containing YSC84-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_038737.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
      Source sequence(s)
      AK141199, AV375458
      Consensus CDS
      CCDS25859.1
      UniProtKB/Swiss-Prot
      O08641, Q6P7V3, Q6PDR3
      Related
      ENSMUSP00000020997.9, ENSMUST00000020997.15
      Conserved Domains (2) summary
      cd11525
      Location:11 → 209
      SYLF_SH3YL1_like; The SYLF domain (also called DUF500), a novel lipid-binding module, of SH3 domain containing Ysc84-like 1 (SH3YL1) and similar proteins
      cd11841
      Location:285 → 338
      SH3_SH3YL1_like; Src homology 3 domain of SH3 domain containing Ysc84-like 1 (SH3YL1) protein

    RNA

    1. NR_110343.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF.
      Source sequence(s)
      AC160932

    2. NR_186254.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC160932

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      30961622..31010159
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003950048.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08641.1 GenPept UniProtKB/Swiss-Prot:O08641

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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