Aatf apoptosis antagonizing transcription factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Aatfprovided by MGI
Official Full Name: apoptosis antagonizing transcription factorprovided by MGI
Primary source: MGI:MGI:1929608
See related: Ensembl:ENSMUSG00000018697 AllianceGenome:MGI:1929608
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Trb; Che-1; 4933415H02Rik; 5830465M17Rik
Summary: Predicted to enable leucine zipper domain binding activity; protein kinase binding activity; and tau protein binding activity. Acts upstream of or within several processes, including negative regulation of amyloid precursor protein biosynthetic process; negative regulation of apoptotic signaling pathway; and regulation of mitotic cell cycle. Located in cytoplasm and nucleolus. Part of transcription regulator complex. Is expressed in several structures, including early conceptus; genitourinary system; liver; nervous system; and tooth. Orthologous to human AATF (apoptosis antagonizing transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 2.3), CNS E11.5 (RPKM 1.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 C; 11 51.3 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (84313682..84404433, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (84422856..84513584, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AATF/Che-1 RNA polymerase II binding protein overexpression reduces the anti-tumor NK-cell cytotoxicity through activating receptors modulation.
Title: AATF/Che-1 RNA polymerase II binding protein overexpression reduces the anti-tumor NK-cell cytotoxicity through activating receptors modulation.
High AATF expression is associated with neuroblastoma.
Title: Link between spermine oxidase and apoptosis antagonizing transcription factor: A new pathway in neuroblastoma.
Study in Aatf conditional knockout mice found that Aatf suppressed RNA:DNA hybrid formation and enabled DNA double strand break repair in vitro. Results suggest that Aatf is a regulator of primary cilia and a modulator of the DNA damage response, connecting two pathogenetic mechanisms in nephronophthisis and related ciliopathies.
Title: Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis.
Che-1 alleviates hypoxia/re-oxygenation-induced cardiomyocyte apoptosis by up-regulation of Nrf2 signaling.
Title: Che-1 attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by upregulation of Nrf2 signaling.
we found that object recognition memory persistence at 7days was impaired in Che-1(+/-) heterozygous mice. This is the first evidence showing that Che-1 is involved in memory processes.
Title: Heterozygous Che-1 KO mice show deficiencies in object recognition memory persistence.
These results identify AATF as a nucleolar-confined c-Jun cofactor whose expression levels and spatial distribution determine the stress-induced activity of c-Jun and the levels of c-Jun-mediated apoptosis.
Title: Nucleolar AATF regulates c-Jun-mediated apoptosis.
Che-1 as a new Pin1 and HDM2 target and confirm its important role in the cellular response to DNA damage.
Title: The prolyl isomerase Pin1 affects Che-1 stability in response to apoptotic DNA damage.
AATF is an endogenous antagonist of Par-4 activity and an effective inhibitor of aberrant amyloid beta 1-42 production and secretion under apoptotic conditions.
Title: AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables leucine zipper domain binding	IEA Inferred from Electronic Annotation more info
enables leucine zipper domain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables tau protein binding	IEA Inferred from Electronic Annotation more info
enables tau protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of embryonic cleavage	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of amyloid precursor protein biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ribosome biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein AATF

Names: rb-binding protein Che-1; traube protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019816.1 → NP_062790.1 protein AATF

See identical proteins and their annotated locations for NP_062790.1

Status: VALIDATED

Source sequence(s)

AF222801

Consensus CDS

CCDS25186.1

UniProtKB/Swiss-Prot

Q7TQN1, Q8C5Q2, Q99P89, Q9JKX4

UniProtKB/TrEMBL

Q3URN5

Related

ENSMUSP00000018841.3, ENSMUST00000018841.3

Conserved Domains (2) summary

pfam08164
Location:430 → 514

TRAUB; Apoptosis-antagonizing transcription factor, C-terminal

pfam13339
Location:188 → 339

AATF-Che1; Apoptosis antagonizing transcription factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

84313682..84404433 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533789.4 → XP_006533852.1 protein AATF isoform X1

UniProtKB/TrEMBL

Q3URN5

Conserved Domains (2) summary

pfam08164
Location:398 → 482

TRAUB; Apoptosis-antagonizing transcription factor, C-terminal

pfam13339
Location:156 → 307

AATF-Che1; Apoptosis antagonizing transcription factor
XM_036156864.1 → XP_036012757.1 protein AATF isoform X2

Conserved Domains (1) summary

pfam13339
Location:189 → 249

AATF-Che1; Apoptosis antagonizing transcription factor