Pspc1 paraspeckle protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pspc1provided by MGI
Official Full Name: paraspeckle protein 1provided by MGI
Primary source: MGI:MGI:1913895
See related: Ensembl:ENSMUSG00000021938 AllianceGenome:MGI:1913895
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PSP1; 5730470C09Rik
Summary: Enables RNA binding activity. Involved in negative regulation of DNA-templated transcription and regulation of circadian rhythm. Located in paraspeckles. Is expressed in several structures, including central nervous system; genitourinary system; and sensory organ. Orthologous to human PSPC1 (paraspeckle component 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 31.2), CNS E14 (RPKM 27.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.4 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (56959898..57015775, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (56722441..56778318, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PSPC1 regulates CHK1 phosphorylation through phase separation and participates in mouse oocyte maturation.
Title: PSPC1 regulates CHK1 phosphorylation through phase separation and participates in mouse oocyte maturation.
These findings highlight a role for PSPC1-dependent RNA maturation in the posttranscriptional control of adipose development and function.
Title: RNA-binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs.
Data indicate involvement of non-POU domain-containing octamer-binding protein (NONO)/paraspeckle protein component 1 (PSPC1)-aldehyde dehydrogenase 1 (NONO/PSPC1-ALDH1A1) in the modulation of Sertoli cells (SCs) response to mono-(2-ethylhexyl) phthalate (MEHP) challenge.
Title: Synergistic upregulation of NONO and PSPC1 regulates Sertoli cell response to MEHP via modulation of ALDH1A1 signaling.
Specific interaction with the nuclear transporter importin alpha2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles.
Title: Specific interaction with the nuclear transporter importin α2 can modulate paraspeckle protein 1 delivery to nuclear paraspeckles.
NONO genetic insufficiency led to upregulation of PSPC1, which replaced NONO in a stable complex with SFPQ.
Title: Double-strand break repair deficiency in NONO knockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog.
A protein complex was identified containing PSPC1, PSF and LMX1B, suggesting the existence of this complex in mesodiencephalic dopaminergic neurons.
Title: LMX1B is part of a transcriptional complex with PSPC1 and PSF.
PSPC1, NONO, and SFPQ form complexes with each other in Sertoli cells and may regulate androgen receptor-mediated transcriptional activity
Title: PSPC1, NONO, and SFPQ are expressed in mouse Sertoli cells and may function as coregulators of androgen receptor-mediated transcription.
mPSP1 may regulate multiple phases of important nuclear events during spermatogenesis.
Title: Expression and functional significance of mouse paraspeckle protein 1 on spermatogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI327109 (e-PCR)
- UniSTS:165908

btcn1695 (e-PCR)
- UniSTS:519245

BE334192 (e-PCR)
- UniSTS:209018

AI449052 (e-PCR)
- UniSTS:180635

Pspc1 (e-PCR), detects polymorphism
- UniSTS:479211

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of innate immune response	IEA Inferred from Electronic Annotation more info
involved_in activation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in membraneless organelle assembly	IEA Inferred from Electronic Annotation more info
involved_in membraneless organelle assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	IEA Inferred from Electronic Annotation more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in paraspeckles	IDA Inferred from Direct Assay more info	PubMed
is_active_in paraspeckles	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: paraspeckle component 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360420.1 → NP_001347349.1 paraspeckle component 1 isoform 2

Status: VALIDATED

Source sequence(s)

AC154731, AK011272, AK017689, CB244768, CN528008
NM_025682.4 → NP_079958.3 paraspeckle component 1 isoform 1

See identical proteins and their annotated locations for NP_079958.3

Status: VALIDATED

Source sequence(s)

AC154731, AK011272, AK017689, CB244768

Consensus CDS

CCDS27151.1

UniProtKB/Swiss-Prot

Q3TUK2, Q8R326, Q9CYH1, Q9D0M8

Related

ENSMUSP00000022507.6, ENSMUST00000022507.13

Conserved Domains (3) summary

cd12949
Location:226 → 319

NOPS_PSPC1; NOPS domain, including C-terminal coiled-coil region, in paraspeckle protein component 1 (PSPC1) and similar proteins

cd12586
Location:80 → 150

RRM1_PSP1; RNA recognition motif 1 in vertebrate paraspeckle protein 1 (PSP1)

cd12589
Location:156 → 235

RRM2_PSP1; RNA recognition motif 2 in vertebrate paraspeckle protein 1 (PSP1 or PSPC1)