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    GPI19 phosphatidylinositol N-acetylglucosaminyltransferase GPI19 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852047, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GPI19
    Official Full Name
    phosphatidylinositol N-acetylglucosaminyltransferase GPI19
    Primary source
    SGD:S000002845
    Locus tag
    YDR437W
    See related
    AllianceGenome:SGD:S000002845; FungiDB:YDR437W; VEuPathDB:YDR437W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to UDP-glycosyltransferase activity. Involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum membrane. Part of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 55. Orthologous to human PIGP (phosphatidylinositol glycan anchor biosynthesis class P). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See GPI19 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1337352..1337774)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene leucine carboxy methyltransferase Neighboring gene salt homeostasis regulator Neighboring gene Thi74p Neighboring gene Lrs4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Candida albicans homologue of PIG-P, CaGpi19p: gene dosage and role in growth and filamentation. Victoria GS, et al. Microbiology (Reading), 2010 Oct. PMID 20576690
    2. Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis. Newman HA, et al. Eukaryot Cell, 2005 Nov. PMID 16278447, Free PMC Article
    3. Jawsamycin exhibits in vivo antifungal properties by inhibiting Spt14/Gpi3-mediated biosynthesis of glycosylphosphatidylinositol. Fu Y, et al. Nat Commun, 2020 Jul 7. PMID 32636417, Free PMC Article
    4. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. Watanabe R, et al. EMBO J, 2000 Aug 15. PMID 10944123, Free PMC Article
    5. Saccharomyces cerevisiae Gle2/Rae1 is involved in septin organization, essential for cell cycle progression. Zander G, et al. Yeast, 2017 Nov. PMID 28776765, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Gpi19 (Ydr437w) is a small but essential subunit of the yeast GPI-GlcNAc transferase.
      Title: Gpi19, the Saccharomyces cerevisiae homologue of mammalian PIG-P, is a subunit of the initial enzyme for glycosylphosphatidylinositol anchor biosynthesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to UDP-glycosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphatidylinositol N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope HDA PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol N-acetylglucosaminyltransferase GPI19
    NP_010725.3
    • Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI; N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI) is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis; shares similarity with mammalian PIG-P

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1337352..1337774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180745.3 → NP_010725.3  TPA: phosphatidylinositol N-acetylglucosaminyltransferase GPI19 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010725.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT64, Q04082
      UniProtKB/TrEMBL
      C7GTP0, C8Z5Z7, G2WBH0, N1PAK1
      Conserved Domains (1) summary
      pfam08510
      Location:3 → 131
      PIG-P
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04082.1

    Gene LinkOut

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