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    LRS4 Lrs4p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852049, updated on 9-Dec-2024

    Summary

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    Official Symbol
    LRS4
    Official Full Name
    Lrs4p
    Primary source
    SGD:S000002847
    Locus tag
    YDR439W
    See related
    AllianceGenome:SGD:S000002847; FungiDB:YDR439W; VEuPathDB:YDR439W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in nucleolus organization; replication-born double-strand break repair via sister chromatid exchange; and spindle attachment to meiosis I kinetochore. Located in nucleolus. Part of monopolin complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See LRS4 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1339676..1340719)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol N-acetylglucosaminyltransferase GPI19 Neighboring gene Thi74p Neighboring gene histone methyltransferase DOT1 Neighboring gene adenine phosphoribosyltransferase APT2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for accurate chromosome segregation. Brito IL, et al. Cell Cycle, 2010 Sep 1. PMID 20818155, Free PMC Article
    2. Dyskerin, tRNA genes, and condensin tether pericentric chromatin to the spindle axis in mitosis. Snider CE, et al. J Cell Biol, 2014 Oct 27. PMID 25332162, Free PMC Article
    3. Condensins promote coorientation of sister chromatids during meiosis I in budding yeast. Brito IL, et al. Genetics, 2010 May. PMID 20194961, Free PMC Article
    4. Structure of the Saccharomyces cerevisiae Hrr25:Mam1 monopolin subcomplex reveals a novel kinase regulator. Ye Q, et al. EMBO J, 2016 Oct 4. PMID 27491543, Free PMC Article
    5. The kinetochore proteins Pcs1 and Mde4 and heterochromatin are required to prevent merotelic orientation. Gregan J, et al. Curr Biol, 2007 Jul 17. PMID 17627824, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Lrs4-Csm1 complex localize to kinetochores during anaphase and is important for ensuring accurate chromosome segregation. (LRS4 protein)
      Title: The Lrs4-Csm1 monopolin complex associates with kinetochores during anaphase and is required for accurate chromosome segregation.
    2. Csm1(Psc1)/Lrs4(Mde4) functions as a molecular clamp, crosslinking kinetochore components to enforce sister chromatid co-orientation in S. cerevisiae meiosis I and to suppress merotelic attachment in S. pombe mitosis.
      Title: The monopolin complex crosslinks kinetochore components to regulate chromosome-microtubule attachments.
    3. Dbf4-dependent Cdc7 kinase (DDK) regulates monopolin localization together with the polo-kinase Cdc5 bound to Spo13, probably through phosphorylation of the monopolin subunit Lrs4
      Title: Dbf4-dependent CDC7 kinase links DNA replication to the segregation of homologous chromosomes in meiosis I.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in homologous chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization to nucleolar rDNA repeats IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rDNA chromatin condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rDNA heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in replication-born double-strand break repair via sister chromatid exchange IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spindle attachment to meiosis I kinetochore IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of monopolin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Lrs4p
    NP_010727.1
    • Nucleolar protein that forms a complex with Csm1p; and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1339676..1340719
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180747.1 → NP_010727.1  TPA: Lrs4p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010727.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT66, Q04087
      UniProtKB/TrEMBL
      A6ZZ33, B3LFM0, C7GTP2, C8Z5Z9, G2WBH2, N1P793
      Conserved Domains (1) summary
      pfam10422
      Location:5 → 232
      LRS4; Monopolin complex subunit LRS4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04087.1

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