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    Zbtb45 zinc finger and BTB domain containing 45 [ Mus musculus (house mouse) ]

    Gene ID: 232879, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Zbtb45provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 45provided by MGI
    Primary source
    MGI:MGI:2685003
    See related
    Ensembl:ENSMUSG00000049600 AllianceGenome:MGI:2685003
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm157; Zfp499
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in 2-cell stage embryo; 4-cell stage embryo; and forebrain. Orthologous to human ZBTB45 (zinc finger and BTB domain containing 45). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 21.0), adrenal adult (RPKM 18.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb45 in Genome Data Viewer
    Location:
    7 A1; 7 7.72 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12737828..12745212, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13005666..13010047, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 446 Neighboring gene solute carrier family 27 (fatty acid transporter), member 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13594963-13595072 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13595132-13595322 Neighboring gene STARR-positive B cell enhancer ABC_E6511 Neighboring gene CRISPRi-validated cis-regulatory element for Slc27a5, Trim28, Ube2m, Zbtb45, Zfp324 and Zfp446 Neighboring gene STARR-positive B cell enhancer ABC_E6512 Neighboring gene predicted gene, 31649 Neighboring gene tripartite motif-containing 28 Neighboring gene STARR-positive B cell enhancer mm9_chr7:13619992-13620293 Neighboring gene charged multivesicular body protein 2A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The novel BTB/POZ and zinc finger factor Zbtb45 is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. Södersten E, et al. Cell Cycle, 2010 Dec 15. PMID 21131782, Free PMC Article
    2. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    3. Mutagenesis of diploid mammalian genes by gene entrapment. Lin Q, et al. Nucleic Acids Res, 2006. PMID 17062627, Free PMC Article
    4. Deterministic and stochastic allele specific gene expression in single mouse blastomeres. Tang F, et al. PLoS One, 2011. PMID 21731673, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that Zbtb45 is a novel regulator of glial differentiation.
      Title: The novel BTB/POZ and zinc finger factor Zbtb45 is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC106784

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 45
    Names
    zinc finger protein 499

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024699.2 → NP_001019870.1  zinc finger and BTB domain-containing protein 45

      See identical proteins and their annotated locations for NP_001019870.1

      Status: VALIDATED

      Source sequence(s)
      BC094359, BQ929674
      Consensus CDS
      CCDS20822.1
      UniProtKB/Swiss-Prot
      Q3TLP9, Q52KG4
      Related
      ENSMUSP00000147298.2, ENSMUST00000210282.2
      Conserved Domains (4) summary
      sd00017
      Location:414 → 434
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:468 → 490
      zf-C2H2; Zinc finger, C2H2 type
      cd18229
      Location:15 → 126
      BTB_POZ_ZBTB45; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45)
      pfam13465
      Location:454 → 479
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001360833.1 → NP_001347762.1  zinc finger and BTB domain-containing protein 45

      Status: VALIDATED

      Source sequence(s)
      AC121301, BC094359
      Consensus CDS
      CCDS20822.1
      UniProtKB/Swiss-Prot
      Q3TLP9, Q52KG4
      Related
      ENSMUSP00000056086.8, ENSMUST00000051390.9
      Conserved Domains (4) summary
      sd00017
      Location:414 → 434
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:468 → 490
      zf-C2H2; Zinc finger, C2H2 type
      cd18229
      Location:15 → 126
      BTB_POZ_ZBTB45; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45)
      pfam13465
      Location:454 → 479
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      12737828..12745212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539803.3 → XP_006539866.1  zinc finger and BTB domain-containing protein 45 isoform X1

      See identical proteins and their annotated locations for XP_006539866.1

      UniProtKB/Swiss-Prot
      Q3TLP9, Q52KG4
      Conserved Domains (4) summary
      sd00017
      Location:414 → 434
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:468 → 490
      zf-C2H2; Zinc finger, C2H2 type
      cd18229
      Location:15 → 126
      BTB_POZ_ZBTB45; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45)
      pfam13465
      Location:454 → 479
      zf-H2C2_2; Zinc-finger double domain

    2. XM_006539804.4 → XP_006539867.1  zinc finger and BTB domain-containing protein 45 isoform X1

      See identical proteins and their annotated locations for XP_006539867.1

      UniProtKB/Swiss-Prot
      Q3TLP9, Q52KG4
      Conserved Domains (4) summary
      sd00017
      Location:414 → 434
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:468 → 490
      zf-C2H2; Zinc finger, C2H2 type
      cd18229
      Location:15 → 126
      BTB_POZ_ZBTB45; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45)
      pfam13465
      Location:454 → 479
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q52KG4.1 GenPept UniProtKB/Swiss-Prot:Q52KG4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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