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    Itih6 inter-alpha-trypsin inhibitor heavy chain family member 6 [ Mus musculus (house mouse) ]

    Gene ID: 634882, updated on 9-Dec-2024

    Summary

    Official Symbol
    Itih6provided by MGI
    Official Full Name
    inter-alpha-trypsin inhibitor heavy chain family member 6provided by MGI
    Primary source
    MGI:MGI:2685232
    See related
    Ensembl:ENSMUSG00000087149 AllianceGenome:MGI:2685232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm386; Itih5l; Itih5l-ps
    Summary
    Orthologous to human ITIH6 (inter-alpha-trypsin inhibitor heavy chain family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in limb E14.5 (RPKM 3.1) and CNS E14 (RPKM 0.3) See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Itih6 in Genome Data Viewer
    Location:
    X F3; X 68.46 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (149609892..149640732)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (150826917..150857407)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 18773 Neighboring gene predicted gene, 24907 Neighboring gene MAGE family member D2 Neighboring gene predicted gene, 54086 Neighboring gene STARR-seq mESC enhancer starr_48073 Neighboring gene polypyrimidine tract binding protein 1 pseudogene Neighboring gene guanine nucleotide binding protein nucleolar 3 like Neighboring gene STARR-positive B cell enhancer ABC_E8765

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General protein information

    Preferred Names
    inter-alpha-trypsin inhibitor heavy chain H6
    Names
    inter-alpha (globulin) inhibitor H5-like, pseudogene

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289875.2NP_001276804.2  inter-alpha-trypsin inhibitor heavy chain H6 precursor

      Status: VALIDATED

      Source sequence(s)
      AL672282
      Related
      ENSMUST00000145639.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      149609892..149640732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017318592.3XP_017174081.1  inter-alpha-trypsin inhibitor heavy chain H6 isoform X1

      Conserved Domains (5) summary
      cd01461
      Location:291475
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      TIGR03788
      Location:62641
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam03154
      Location:6331007
      Atrophin-1; Atrophin-1 family
      pfam06668
      Location:11001229
      ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
      cl02699
      Location:51161
      VIT; Vault protein inter-alpha-trypsin domain
    2. XM_017318593.3XP_017174082.1  inter-alpha-trypsin inhibitor heavy chain H6 isoform X2

      Conserved Domains (4) summary
      cd01461
      Location:291475
      vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
      TIGR03788
      Location:62641
      marine_srt_targ; marine proteobacterial sortase target protein
      pfam03154
      Location:6331007
      Atrophin-1; Atrophin-1 family
      cl02699
      Location:51161
      VIT; Vault protein inter-alpha-trypsin domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_003597.1: Suppressed sequence

      Description
      NR_003597.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.