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    Ech1 enoyl coenzyme A hydratase 1, peroxisomal [ Mus musculus (house mouse) ]

    Gene ID: 51798, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ech1provided by MGI
    Official Full Name
    enoyl coenzyme A hydratase 1, peroxisomalprovided by MGI
    Primary source
    MGI:MGI:1858208
    See related
    Ensembl:ENSMUSG00000053898 AllianceGenome:MGI:1858208
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity. Predicted to be involved in fatty acid beta-oxidation. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; liver; and nervous system. Orthologous to human ECH1 (enoyl-CoA hydratase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 764.2), kidney adult (RPKM 330.1) and 19 other tissues See more
    Orthologs
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    Genomic context

    See Ech1 in Genome Data Viewer
    Location:
    7 B1; 7 16.94 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28524763..28531664)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28825338..28832239)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA lysine 24 (anticodon TTT) Neighboring gene Ras and Rab interactor-like Neighboring gene STARR-seq mESC enhancer starr_18438 Neighboring gene STARR-positive B cell enhancer ABC_E156 Neighboring gene STARR-positive B cell enhancer ABC_E8158 Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene STARR-seq mESC enhancer starr_18440 Neighboring gene lectin, galactose binding, soluble 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29650992-29651179 Neighboring gene lectin, galactose binding, soluble 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC107274

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity  
    enables isomerase activity  
    Component Evidence Code Pubs
    located_in mitochondrion PubMed 
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in peroxisome  

    General protein information

    Preferred Names
    delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
    Names
    dienoyl-CoA isomerase
    peroxisomal/mitochondrial dienoyl-CoA isomerase
    NP_058052.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016772.1NP_058052.1  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_058052.1

      Status: PROVISIONAL

      Source sequence(s)
      AF030343
      Consensus CDS
      CCDS21057.1
      UniProtKB/Swiss-Prot
      O35459, Q5M8P6
      Related
      ENSMUSP00000066092.7, ENSMUST00000066264.13
      Conserved Domains (1) summary
      cl23717
      Location:53317
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      28524763..28531664
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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