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    Abca17 ATP-binding cassette, sub-family A member 17 [ Mus musculus (house mouse) ]

    Gene ID: 381072, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Abca17provided by MGI
    Official Full Name
    ATP-binding cassette, sub-family A member 17provided by MGI
    Primary source
    MGI:MGI:3625331
    See related
    Ensembl:ENSMUSG00000035435 AllianceGenome:MGI:3625331
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable ATPase-coupled transmembrane transporter activity and lipid transporter activity. Acts upstream of or within neutral lipid metabolic process. Located in endoplasmic reticulum. Is expressed in lymph node; stomach; testis; and thyroid gland. Orthologous to human ABCA17P (ATP binding cassette subfamily A member 17, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 5.8), lung adult (RPKM 1.7) and 7 other tissues See more
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    Genomic context

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    See Abca17 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.35 cM
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24483231..24570079, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24264257..24352058, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene cyclin F Neighboring gene STARR-seq mESC enhancer starr_42081 Neighboring gene microRNA 5134 Neighboring gene STARR-seq mESC enhancer starr_42082 Neighboring gene microRNA 6965 Neighboring gene STARR-seq mESC enhancer starr_42083 Neighboring gene STARR-positive B cell enhancer ABC_E9436 Neighboring gene ATP-binding cassette, sub-family A member 3 Neighboring gene STARR-seq mESC enhancer starr_42084 Neighboring gene predicted gene, 25618 Neighboring gene RIKEN cDNA D330041H03 gene Neighboring gene STARR-positive B cell enhancer ABC_E3188

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ABCA17 mediates sterol efflux from mouse spermatozoa plasma membranes. Morales CR, et al. Histol Histopathol, 2012 Mar. PMID 22237709
    2. Cloning of ABCA17, a novel rodent sperm-specific ABC (ATP-binding cassette) transporter that regulates intracellular lipid metabolism. Ban N, et al. Biochem J, 2005 Jul 15. PMID 15810880, Free PMC Article
    3. The human ortholog of the rodent testis-specific ABC transporter Abca17 is a ubiquitously expressed pseudogene (ABCA17P) and shares a common 5' end with ABCA3. Piehler AP, et al. BMC Mol Biol, 2006 Sep 12. PMID 16968533, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lipid transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neutral lipid metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ATP-binding cassette sub-family A member 17
    Names
    ATP-binding cassette, sub-family A (ABC1), member 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031621.3 → NP_001026792.2  ATP-binding cassette sub-family A member 17

      See identical proteins and their annotated locations for NP_001026792.2

      Status: VALIDATED

      Source sequence(s)
      AC117577
      Consensus CDS
      CCDS37485.1
      UniProtKB/Swiss-Prot
      E9PX95, Q4H4D7
      Related
      ENSMUSP00000112538.2, ENSMUST00000121226.8
      Conserved Domains (1) summary
      TIGR01257
      Location:209 → 1684
      rim_protein; retinal-specific rim ABC transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      24483231..24570079 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317534.3 → XP_017173023.1  ATP-binding cassette sub-family A member 17 isoform X2

      Conserved Domains (1) summary
      TIGR01257
      Location:209 → 1677
      rim_protein; retinal-specific rim ABC transporter

    2. XM_017317532.3 → XP_017173021.1  ATP-binding cassette sub-family A member 17 isoform X1

      UniProtKB/Swiss-Prot
      E9PX95, Q4H4D7
      Conserved Domains (1) summary
      TIGR01257
      Location:209 → 1684
      rim_protein; retinal-specific rim ABC transporter

    3. XM_017317536.3 → XP_017173025.1  ATP-binding cassette sub-family A member 17 isoform X3

      Conserved Domains (1) summary
      TIGR01257
      Location:209 → 1645
      rim_protein; retinal-specific rim ABC transporter

    4. XM_006524484.5 → XP_006524547.1  ATP-binding cassette sub-family A member 17 isoform X8

      Conserved Domains (1) summary
      TIGR01257
      Location:44 → 1108
      rim_protein; retinal-specific rim ABC transporter

    5. XM_006524482.5 → XP_006524545.1  ATP-binding cassette sub-family A member 17 isoform X7

      See identical proteins and their annotated locations for XP_006524545.1

      Conserved Domains (1) summary
      TIGR01257
      Location:51 → 1115
      rim_protein; retinal-specific rim ABC transporter

    6. XM_017317540.2 → XP_017173029.1  ATP-binding cassette sub-family A member 17 isoform X9

      Conserved Domains (1) summary
      TIGR01257
      Location:1 → 1048
      rim_protein; retinal-specific rim ABC transporter

    7. XM_017317537.3 → XP_017173026.1  ATP-binding cassette sub-family A member 17 isoform X4

      Conserved Domains (1) summary
      TIGR01257
      Location:209 → 1560
      rim_protein; retinal-specific rim ABC transporter

    8. XM_017317539.3 → XP_017173028.1  ATP-binding cassette sub-family A member 17 isoform X5

      Conserved Domains (1) summary
      TIGR01257
      Location:209 → 1314
      rim_protein; retinal-specific rim ABC transporter

    9. XM_006524481.5 → XP_006524544.1  ATP-binding cassette sub-family A member 17 isoform X6

      Conserved Domains (1) summary
      TIGR01257
      Location:209 → 1246
      rim_protein; retinal-specific rim ABC transporter

    RNA

    1. XR_001782084.3 RNA Sequence

    2. XR_001782083.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E9PX95.1 GenPept UniProtKB/Swiss-Prot:E9PX95

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