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    Gm12250 predicted gene 12250 [ Mus musculus (house mouse) ]

    Gene ID: 631323, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gm12250provided by MGI
    Official Full Name
    predicted gene 12250provided by MGI
    Primary source
    MGI:MGI:3649299
    See related
    AllianceGenome:MGI:3649299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Irgb10
    Summary
    Enables G protein activity and membrane destabilizing activity. Involved in several processes, including defense response to other organism; positive regulation of defense response; and protein homooligomerization. Acts upstream of or within response to bacterium. Is active in symbiont cell surface. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in large intestine adult (RPKM 2.7), spleen adult (RPKM 1.5) and 20 other tissues See more
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    Genomic context

    See Gm12250 in Genome Data Viewer
    Location:
    11 B1.3; 11 35.96 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (58074669..58081024)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (58183843..58190198)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene gem nuclear organelle associated protein 5 Neighboring gene STARR-positive B cell enhancer ABC_E5229 Neighboring gene mitochondrial ribosomal protein L22 Neighboring gene STARR-positive B cell enhancer ABC_E8877 Neighboring gene interferon gamma induced GTPase Neighboring gene STARR-positive B cell enhancer ABC_E8408 Neighboring gene immunity-related GTPase family M member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity PubMed 
    enables GTP binding  
    enables GTPase activity  
    enables membrane destabilizing activity PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome assembly  
    involved_in cellular response to interferon-beta  
    involved_in defense response to bacterium PubMed 
    involved_in defense response to fungus PubMed 
    involved_in defense response to protozoan PubMed 
    involved_in defense response to virus PubMed 
    involved_in disruption of plasma membrane integrity in another organism PubMed 
    involved_in innate immune response  
    involved_in innate immune response  
    involved_in killing of cells of another organism PubMed 
    involved_in positive regulation of AIM2 inflammasome complex assembly PubMed 
    involved_in positive regulation of NLRP3 inflammasome complex assembly PubMed 
    involved_in positive regulation of pyroptotic inflammatory response PubMed 
    involved_in protein homooligomerization PubMed 
    acts_upstream_of_or_within response to bacterium PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane  
    is_active_in endoplasmic reticulum membrane  
    is_active_in symbiont cell surface PubMed 

    General protein information

    Preferred Names
    interferon-gamma-inducible GTPase 10
    Names
    interferon-gamma-inducible p47 GTPase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135115.1NP_001128587.1  interferon-gamma-inducible GTPase 10

      See identical proteins and their annotated locations for NP_001128587.1

      Status: PROVISIONAL

      Source sequence(s)
      AL928857
      UniProtKB/Swiss-Prot
      Q0GUM2, Q0GUM3
      UniProtKB/TrEMBL
      U5NFV2
      Conserved Domains (2) summary
      cd04104
      Location:68263
      p47_IIGP_like; p47 GTPase family includes IGTP, TGTP/Mg21, IRG-47, GTPI, LRG-47, and IIGP1
      pfam05049
      Location:34407
      IIGP; Interferon-inducible GTPase (IIGP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      58074669..58081024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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