TAF14 TATA-binding protein-associated factor TAF14 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: TAF14
Official Full Name: TATA-binding protein-associated factor TAF14
Primary source: SGD:S000006050
Locus tag: YPL129W
See related: AllianceGenome:SGD:S000006050; FungiDB:YPL129W; VEuPathDB:YPL129W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ANC1; SWP29; TAF30; TFG3
Summary: Enables DNA binding activity and RNA polymerase II general transcription initiation factor activity. Involved in chromatin remodeling and transcription initiation at RNA polymerase II promoter. Located in nucleus. Part of RNA polymerase II, holoenzyme; chromatin; and mediator complex. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 4. Orthologous to human MLLT1 (MLLT1 super elongation complex subunit); MLLT3 (MLLT3 super elongation complex subunit); and YEATS2 (YEATS domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TAF14 in Genome Data Viewer

Location:: chromosome: XVI

Exon count:: 2

Sequence:: Chromosome: XVI; NC_001148.4 (305298..306137)

Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001148.4

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptional regulator Taf14 binds DNA and is required for the function of transcription factor TFIID in the absence of histone H2A.Z.
Title: Transcriptional regulator Taf14 binds DNA and is required for the function of transcription factor TFIID in the absence of histone H2A.Z.
Taf2 mediates DNA binding of Taf14.
Title: Taf2 mediates DNA binding of Taf14.
Taf14 is required for the stabilization of transcription pre-initiation complex in Saccharomyces cerevisiae.
Title: Taf14 is required for the stabilization of transcription pre-initiation complex in Saccharomyces cerevisiae.
Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation.
Title: Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation.
Histone crotonylation and Taf14 participate in the repression of energy-demanding gene expression in S.cerevisiae.
Title: Recognition of Histone Crotonylation by Taf14 Links Metabolic State to Gene Expression.
a novel role for Taf14 in repression and derepression of stress induced genes
Title: A meta-analysis reveals complex regulatory properties at Taf14-repressed genes.
the mechanism through which Taf14 suppresses taf2(ts) alleles, shedding light on how Taf2-Taf14 interaction contributes to TFIID complex organization and identifying a potential role for Taf14 in mediating TFIID-chromatin interactions.
Title: The C Terminus of the RNA Polymerase II Transcription Factor IID (TFIID) Subunit Taf2 Mediates Stable Association of Subunit Taf14 into the Yeast TFIID Complex.
the YEATS domain of Taf14, a member of key transcriptional and chromatin-modifying complexes in yeast, is a selective reader of histone H3 Lys9 acetylation (H3K9ac).
Title: Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response.
Taf14 is involved in transcriptional activation of Saccharomyces cerevisiae and the YEATS domain of Taf14 might play a negative role in cell growth.
Title: Solution structure of the Taf14 YEATS domain and its roles in cell growth of Saccharomyces cerevisiae.
show here that the YEATS domain is not necessary for Taf14's association with transcription stimulatory activity and chromatin remodeling complexes.
Title: The YEATS domain of Taf14 in Saccharomyces cerevisiae has a negative impact on cell growth.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II general transcription initiation factor activity	IDA Inferred from Direct Assay more info	PubMed
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in transcription initiation at RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of Ino80 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ino80 complex	IDA Inferred from Direct Assay more info	PubMed
part_of Ino80 complex	IPI Inferred from Physical Interaction more info	PubMed
part_of NuA3 histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of NuA3a histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of NuA3b histone acetyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SWI/SNF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SWI/SNF complex	IDA Inferred from Direct Assay more info	PubMed
located_in chromatin	IEA Inferred from Electronic Annotation more info
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of transcription factor TFIID complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIID complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIF complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription factor TFIIF complex	IDA Inferred from Direct Assay more info	PubMed
part_of transcription factor TFIIF complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: TATA-binding protein-associated factor TAF14

NP_015196.1

Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes; involved in RNA polymerase II transcription initiation and in chromatin modification; serves as an additional DNA binding domain for the complex; contains a YEATS domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001148.4 Reference assembly

Range

305298..306137

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183943.1 → NP_015196.1 TPA: TATA-binding protein-associated factor TAF14 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015196.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W3N8, P35189, Q02460

UniProtKB/TrEMBL

A6ZWC3, B3LKU6, C8ZIQ1, G2WP52, N1NVV6

Conserved Domains (1) summary

COG5033
Location:2 → 242

TFG3; Transcription initiation factor IIF, auxiliary subunit [Transcription]