Rln1 relaxin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rln1provided by RGD
Official Full Name: relaxin 1provided by RGD
Primary source: RGD:3579
See related: EnsemblRapid:ENSRNOG00000060867 AllianceGenome:RGD:3579
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RELAX
Summary: Predicted to enable signaling receptor binding activity. Involved in negative regulation of apoptotic process and regulation of cell population proliferation. Acts upstream of or within adenylate cyclase-modulating G protein-coupled receptor signaling pathway and regulation of nitric oxide mediated signal transduction. Predicted to be located in extracellular region. Orthologous to several human genes including RLN1 (relaxin 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 4.1) and Muscle (RPKM 0.4) See more
Orthologs: human all
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Genomic context

Location:: 1q52

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (236493532..236496541, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (227079960..227082960, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (247483298..247486331, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Relaxin reverses maladaptive remodeling of the aged heart through Wnt-signaling.
Title: Relaxin reverses maladaptive remodeling of the aged heart through Wnt-signaling.
Relaxin-1 mRNA in the hearts of diabetic rats was significantly increased and that relaxin-3 mRNA expression at different time points was decreased. In addition, significant down-regulation of the mRNA expression of RXFP1 and RXFP3 was observed at 4 weeks after Streptozocin.
Title: Alterations of relaxin and its receptor system components in experimental diabetic cardiomyopathy rats.
The digestive tract has been shown to express relaxin receptors; the hormone appears to exert site-specific effects acting at the neural or at the smooth muscle level, mainly by a nitric oxide-mediated mechanism. (Review)
Title: Site-related Effects of Relaxin in the Gastrointestinal Tract Through Nitric Oxide Signalling: An Updated Report.
The aim of the present study was to explore a role of relaxin at specific stages of spermatogenesis using a co-culture of rat Sertoli and germ cells.
Title: Effects of relaxin in a co-culture of Sertoli and germ cells.
We have shown that relaxin stimulates Sertoli cell proliferation through the activation of MEK/ERK1/2 and PI3K/AKT pathways.
Title: Relaxin and Sertoli cell proliferation.
Raxin is a mediator of the refractoriness of the mesangial cells to angiotensin II during pregnancy.
Title: Mesangial cells cultured from pregnant rats display reduced reactivity to angiotensin II: the role of relaxin, nitric oxide and AT2 receptor.
Data demonstrate a functional role for relaxin in mediating uterine artery compliance in pregnant rats, which may be necessary to maintain adequate uterine blood flow to the uterus and placenta.
Title: Relaxin mediates uterine artery compliance during pregnancy and increases uterine blood flow.
A novel G-quadruplex in the relaxin gene, is reported.
Title: The formation and stabilization of a novel G-quadruplex in the 5'-flanking region of the relaxin gene.
Rln-1 was localized in the granulosa cells of the ovarian follicles, and immunoreactivity against Rln 1 was increased by orthodontic tooth movement in a time-dependent manner.
Title: Relaxin is up-regulated in the rat ovary by orthodontic tooth movement.
High glucose concentration could stimulate the expression of endogenous relaxin.
Title: Effects of recombinant human relaxin upon proliferation of cardiac fibroblast and synthesis of collagen under high glucose condition.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

RH94497 (e-PCR)
- UniSTS:119745

D1Bda60 (e-PCR)
- UniSTS:239813

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone activity	TAS Traceable Author Statement more info	PubMed
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within developmental growth	ISO Inferred from Sequence Orthology more info
involved_in mammary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nipple development	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within prostate gland growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostate gland growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of body fluid levels	TAS Traceable Author Statement more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of nitric oxide mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: prorelaxin 1

Names: Relaxin 1 (H1); preprorelaxin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013413.2 → NP_038199.1 prorelaxin 1 precursor

See identical proteins and their annotated locations for NP_038199.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P01347, Q78N50

UniProtKB/TrEMBL

A6I0V8

Related

ENSRNOP00000072430.3, ENSRNOT00000088193.3

Conserved Domains (2) summary

cd04365
Location:145 → 186

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...

cl02453
Location:33 → 72

IlGF_like; Insulin/insulin-like growth factor/relaxin family; insulin family of proteins. Members include a number of active peptides which are evolutionary related including insulin, relaxin, prorelaxin, insulin-like growth factors I and II, mammalian Leydig ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

236493532..236496541 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006231196.5 → XP_006231258.1 prorelaxin 1 isoform X1

See identical proteins and their annotated locations for XP_006231258.1

UniProtKB/TrEMBL

Q7TQA2

Conserved Domains (1) summary

cd04365
Location:144 → 185

IlGF_relaxin_like; IlGF_like family, relaxin_like subgroup, specific to vertebrates. Members include a number of active peptides including (pro)relaxin, mammalian Leydig cell-specific insulin-like peptide (gene INSL3), early placenta insulin-like peptide (ELIP; gene INSL4), ...