Fgf14 fibroblast growth factor 14 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fgf14provided by RGD
Official Full Name: fibroblast growth factor 14provided by RGD
Primary source: RGD:620165
See related: EnsemblRapid:ENSRNOG00000009288 AllianceGenome:RGD:620165
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fhf4; FGF-14
Summary: Enables growth factor activity. Acts upstream of or within several processes, including positive regulation of high voltage-gated calcium channel activity; regulation of postsynaptic membrane potential; and regulation of synaptic vesicle recycling. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant cerebellar ataxia. Orthologous to human FGF14 (fibroblast growth factor 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Restricted expression toward (RPKM 168.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 15q25

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (107442800..108086486, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (101045033..101679888, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (110382274..111077027, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells.
Title: Nav1.3 and FGF14 are primary determinants of the TTX-sensitive sodium current in mouse adrenal chromaffin cells.
identified the PI3K/Akt pathway, the cell-cycle regulator Wee1 kinase, and protein kinase C (PKC) as prospective regulatory nodes of neuronal excitability through modulation of the FGF14:Nav1.6 complex.
Title: Identifying a kinase network regulating FGF14:Nav1.6 complex assembly using split-luciferase complementation.
FGF14 regulates presynaptic Ca2+ channels in granule cell and EPSCs in Purkinje cells.
Title: FGF14 regulates presynaptic Ca2+ channels and synaptic transmission.
inhibition of GSK3 reduces the assembly of the FGF14.Nav channel complex, modifies FGF14-dependent regulation of Na(+) currents, and induces dissociation and subcellular redistribution of the native FGF14.Nav channel complex in hippocampal neurons.
Title: The fibroblast growth factor 14·voltage-gated sodium channel complex is a new target of glycogen synthase kinase 3 (GSK3).

Submit: New GeneRIF Correction

General gene information

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Markers

D15Got101 (e-PCR)
- UniSTS:113833

BF414602 (e-PCR)
- UniSTS:248745

Fgf14 (e-PCR), detects polymorphism
- UniSTS:507872

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables heparin binding	ISO Inferred from Sequence Orthology more info
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within adult locomotory behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuromuscular process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of high voltage-gated calcium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of sodium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of postsynaptic membrane potential	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic vesicle recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of voltage-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: fibroblast growth factor 14

Names: FGF homologus factor 4b; fibroblast growth factor homologous factor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411965.1 → NP_001398894.1 fibroblast growth factor 14 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/TrEMBL

A0A8I6A9Y8, A6HUN2, Q794I6

Related

ENSRNOP00000088042.1, ENSRNOT00000102677.2
NM_022223.3 → NP_071559.2 fibroblast growth factor 14 isoform 1

See identical proteins and their annotated locations for NP_071559.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000015

UniProtKB/Swiss-Prot

Q8R5L7

UniProtKB/TrEMBL

A6HUN3

Related

ENSRNOP00000042838.5, ENSRNOT00000041551.7

Conserved Domains (1) summary

pfam00167
Location:72 → 197

FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

107442800..108086486 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093636.2 → XP_038949564.1 fibroblast growth factor 14 isoform X1

UniProtKB/TrEMBL

A0A8I6A9Y8, A6HUN2, Q794I6

Conserved Domains (1) summary

pfam00167
Location:77 → 202

FGF; Fibroblast growth factor
XM_063274614.1 → XP_063130684.1 fibroblast growth factor 14 isoform X2

UniProtKB/TrEMBL

Q8R4X0
XM_039093639.2 → XP_038949567.1 fibroblast growth factor 14 isoform X2

UniProtKB/TrEMBL

Q8R4X0

Conserved Domains (1) summary

pfam00167
Location:1 → 113

FGF; Fibroblast growth factor
XM_063274613.1 → XP_063130683.1 fibroblast growth factor 14 isoform X2

UniProtKB/TrEMBL

Q8R4X0
XM_063274611.1 → XP_063130681.1 fibroblast growth factor 14 isoform X2

UniProtKB/TrEMBL

Q8R4X0
XM_063274612.1 → XP_063130682.1 fibroblast growth factor 14 isoform X2

UniProtKB/TrEMBL

Q8R4X0