Rnf19b ring finger protein 19B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf19bprovided by MGI
Official Full Name: ring finger protein 19Bprovided by MGI
Primary source: MGI:MGI:1922484
See related: Ensembl:ENSMUSG00000028793 AllianceGenome:MGI:1922484
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ibrdc3; 4930534K13Rik; 4930555L03Rik
Summary: Predicted to enable ubiquitin binding activity; ubiquitin conjugating enzyme binding activity; and ubiquitin protein ligase activity. Acts upstream of or within natural killer cell mediated cytotoxicity. Located in cytolytic granule. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human RNF19B (ring finger protein 19B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 168.3), ovary adult (RPKM 52.6) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D2.2; 4 62.76 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (128951871..128978319)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (129058144..129084526)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results indicate that natural killer lytic-associated molecule (NKLAM/RNF19b) plays a role in regulating the production of pro-inflammatory cytokines during viral infection.
Title: Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model.
E3 ubiquitin ligase NKLAM positively regulates macrophage inducible nitric oxide synthase expression.
Title: E3 ubiquitin ligase NKLAM positively regulates macrophage inducible nitric oxide synthase expression.
Data show that Natural Killer Lytic-Associated Molecule (NKLAM) is a component of macrophage phagosomes and is involved in macrophage bactericidal functions.
Title: E3 ubiquitin ligase NKLAM is a macrophage phagosome protein and plays a role in bacterial killing.
support the role for NKLAM in NK function both in vitro and in vivo.
Title: Impaired NK cytolytic activity and enhanced tumor growth in NK lytic-associated molecule-deficient mice.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126375 (e-PCR)
- UniSTS:163083

R74711 (e-PCR)
- UniSTS:125513

NoName (e-PCR)
- UniSTS:493470

RH130445 (e-PCR)
- UniSTS:213729

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin binding	ISS Inferred from Sequence or Structural Similarity more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within natural killer cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytolytic granule	IBA Inferred from Biological aspect of Ancestor more info
located_in cytolytic granule	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF19B

Names: IBR domain containing 3; IBR domain-containing protein 3; natural killer lytic-associated molecule

NP_001355692.1

EC 2.3.2.31

NP_083495.1

EC 2.3.2.31

XP_036020406.1

EC 2.3.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001368763.1 → NP_001355692.1 E3 ubiquitin-protein ligase RNF19B isoform 1

Status: VALIDATED

Source sequence(s)

AL606977

Consensus CDS

CCDS89829.1

UniProtKB/Swiss-Prot

A0AUN9, A2A7Q9, Q7TT05

Related

ENSMUSP00000030584.5, ENSMUST00000030584.11

Conserved Domains (4) summary

smart00647
Location:184 → 248

IBR; In Between Ring fingers

pfam01485
Location:280 → 318

IBR; IBR domain, a half RING-finger domain

cd16776
Location:116 → 169

RING-HC_RBR_RNF19B; RING finger, HC subclass, found in RING finger protein 19B (RNF19B) and similar proteins

cl00570
Location:344 → 433

AzlC; AzlC protein
NM_029219.2 → NP_083495.1 E3 ubiquitin-protein ligase RNF19B isoform 2

See identical proteins and their annotated locations for NP_083495.1

Status: VALIDATED

Source sequence(s)

AL606977

Consensus CDS

CCDS51305.1

UniProtKB/TrEMBL

E9Q2L7

Related

ENSMUSP00000131373.2, ENSMUST00000168461.8

Conserved Domains (4) summary

smart00647
Location:184 → 248

IBR; In Between Ring fingers

pfam01485
Location:279 → 317

IBR; IBR domain, a half RING-finger domain

pfam13639
Location:116 → 163

zf-RING_2; Ring finger domain

cl00570
Location:343 → 432

AzlC; AzlC protein