Ctsc cathepsin C [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ctscprovided by RGD
Official Full Name: cathepsin Cprovided by RGD
Primary source: RGD:2445
See related: EnsemblRapid:ENSRNOG00000016496 AllianceGenome:RGD:2445
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CATC; DPPI; DPP-I
Summary: Enables several functions, including chloride ion binding activity; identical protein binding activity; and protein-folding chaperone binding activity. Involved in positive regulation of proteolysis involved in protein catabolic process. Located in lysosome. Biomarker of brain ischemia; hypertension; and obesity. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (cathepsin C). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Liver (RPKM 604.8), Kidney (RPKM 269.7) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (151440860..151472430)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (142028386..142059841)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (151918514..151949979)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cathepsin C Regulates Cytokine-Induced Apoptosis in beta-Cell Model Systems.
Title: Cathepsin C Regulates Cytokine-Induced Apoptosis in β-Cell Model Systems.
Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia.
Title: Cathepsin C is a novel mediator of podocyte and renal injury induced by hyperglycemia.
Findings demonstrate the role of DPPI in regulating MCs and NPs activation, and modulating proteolysis in the process of RA.
Title: The regulatory role of Dipeptidyl peptidase I on the activation of immune granulocytes.
Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.
Title: Neutrophilic Cathepsin C Is Maturated by a Multistep Proteolytic Process and Secreted by Activated Cells during Inflammatory Lung Diseases.

Submit: New GeneRIF Correction

General gene information

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Markers

BF389062 (e-PCR)
- UniSTS:245357

AA800884 (e-PCR)
- UniSTS:249984

RH140897 (e-PCR)
- UniSTS:222913

RH127861 (e-PCR)
- UniSTS:211171

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chloride ion binding	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	NAS Non-traceable Author Statement more info	PubMed
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables dipeptidyl-peptidase activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activator activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-folding chaperone binding	IPI Inferred from Physical Interaction more info	PubMed
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteolysis involved in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	TAS Traceable Author Statement more info	PubMed
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dipeptidyl peptidase 1

Names: cathepsin J; dipeptidyl peptidase I; dipeptidyl transferase

NP_058793.1

EC 3.4.14.1

XP_008757859.1

EC 3.4.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017097.2 → NP_058793.1 dipeptidyl peptidase 1 precursor

See identical proteins and their annotated locations for NP_058793.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P80067, P80068

UniProtKB/TrEMBL

A6I5Z1

Related

ENSRNOP00000022342.3, ENSRNOT00000022342.7

Conserved Domains (3) summary

cd02621
Location:230 → 459

Peptidase_C1A_CathepsinC; Cathepsin C; also known as Dipeptidyl Peptidase I (DPPI), an atypical papain-like cysteine peptidase with chloride dependency and dipeptidyl aminopeptidase activity, resulting from its tetrameric structure which limits substrate access. Each subunit of ...

cl28439
Location:168 → 204

Pox_I6; Poxvirus I6-like family

pfam08773
Location:25 → 138

CathepsinC_exc; Cathepsin C exclusion domain