Megf10 multiple EGF-like domains 10 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Megf10provided by RGD
Official Full Name: multiple EGF-like domains 10provided by RGD
Primary source: RGD:735084
See related: EnsemblRapid:ENSRNOG00000013674 AllianceGenome:RGD:735084
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable Notch binding activity; complement component C1q complex binding activity; and scavenger receptor activity. Predicted to be involved in several processes, including myoblast development; positive regulation of myoblast proliferation; and skeletal muscle satellite cell proliferation. Predicted to act upstream of or within apoptotic process involved in development; engulfment of apoptotic cell; and recognition of apoptotic cell. Predicted to be located in phagocytic cup. Human ortholog(s) of this gene implicated in congenital myopathy 10B and early-onset myopathy-areflexia-respiratory distress-dysphagia syndrome. Orthologous to human MEGF10 (multiple EGF like domains 10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 47.1), Muscle (RPKM 37.0) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q12.1

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (52803292..52953431)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (50605231..50755441)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (52215652..52366212)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables Notch binding	IBA Inferred from Biological aspect of Ancestor more info
enables Notch binding	ISO Inferred from Sequence Orthology more info
enables complement component C1q complex binding	ISO Inferred from Sequence Orthology more info
enables scavenger receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in apoptotic cell clearance	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process involved in development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within engulfment of apoptotic cell	ISO Inferred from Sequence Orthology more info
involved_in homotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in muscle cell development	ISO Inferred from Sequence Orthology more info
involved_in muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in myelination	NAS Non-traceable Author Statement more info	PubMed
involved_in myoblast development	ISO Inferred from Sequence Orthology more info
involved_in myoblast migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of myoblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within recognition of apoptotic cell	ISO Inferred from Sequence Orthology more info
involved_in regulation of muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle satellite cell activation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle satellite cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle satellite cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: multiple epidermal growth factor-like domains protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100657.1 → NP_001094127.1 multiple epidermal growth factor-like domains protein 10 precursor

See identical proteins and their annotated locations for NP_001094127.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

F1MAP4

Related

ENSRNOP00000036049.4, ENSRNOT00000037901.8

Conserved Domains (3) summary

smart00180
Location:281 → 318

EGF_Lam; Laminin-type epidermal growth factor-like domai

pfam07546
Location:32 → 99

EMI; EMI domain

cl21504
Location:542 → 587

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

52803292..52953431

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096646.2 → XP_038952574.1 multiple epidermal growth factor-like domains protein 10 isoform X1

UniProtKB/TrEMBL

F1MAP4

Conserved Domains (3) summary

smart00180
Location:281 → 318

EGF_Lam; Laminin-type epidermal growth factor-like domai

pfam07546
Location:32 → 99

EMI; EMI domain

cl21504
Location:542 → 587

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
XM_006254747.4 → XP_006254809.1 multiple epidermal growth factor-like domains protein 10 isoform X1

See identical proteins and their annotated locations for XP_006254809.1

UniProtKB/TrEMBL

F1MAP4

Conserved Domains (3) summary

smart00180
Location:281 → 318

EGF_Lam; Laminin-type epidermal growth factor-like domai

pfam07546
Location:32 → 99

EMI; EMI domain

cl21504
Location:542 → 587

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...