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    Ctla4 cytotoxic T-lymphocyte-associated protein 4 [ Mus musculus (house mouse) ]

    Gene ID: 12477, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ctla4provided by MGI
    Official Full Name
    cytotoxic T-lymphocyte-associated protein 4provided by MGI
    Primary source
    MGI:MGI:88556
    See related
    Ensembl:ENSMUSG00000026011 AllianceGenome:MGI:88556
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cd152; Ly-56; Ctla-4
    Summary
    This gene is a member of the immunoglobulin superfamily, and encodes a protein that functions as a negative regulator of T-cell responses. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2013]
    Expression
    Biased expression in thymus adult (RPKM 1.4), spleen adult (RPKM 0.8) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ctla4 in Genome Data Viewer
    Location:
    1 C2; 1 30.58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (60948184..60954991)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (60909025..60915832)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39650 Neighboring gene STARR-positive B cell enhancer ABC_E8981 Neighboring gene STARR-positive B cell enhancer ABC_E1547 Neighboring gene ribosomal protein L18, pseudogene 1 Neighboring gene predicted gene, 34649 Neighboring gene dynein light chain LC8-type 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells. Foy SP, et al. Cancer Immunol Immunother, 2016 May. PMID 26961085, Free PMC Article
    2. The soluble CTLA-4 splice variant protects from type 1 diabetes and potentiates regulatory T-cell function. Gerold KD, et al. Diabetes, 2011 Jul. PMID 21602513, Free PMC Article
    3. CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization. van Wijk F, et al. J Immunol, 2005 Jan 1. PMID 15611239
    4. CTLA-4 engagement acts as a brake on CD4+ T cell proliferation and cytokine production but is not required for tuning T cell reactivity in adaptive tolerance. Inobe M, et al. J Immunol, 2004 Dec 15. PMID 15585846
    5. Role of CTLA-4 in the activation of single- and double-positive thymocytes. Kwon H, et al. J Immunol, 2004 Dec 1. PMID 15557155

    See all (391) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High PD-1 and CTLA-4 expression correlates with host immune suppression in patients and a mouse model infected with Echinococcus multilocularis.
      Title: High PD-1 and CTLA-4 expression correlates with host immune suppression in patients and a mouse model infected with Echinococcus multilocularis.
    2. Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation.
      Title: Rapid turnover of CTLA4 is associated with a complex architecture of reversible ubiquitylation.
    3. CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation.
      Title: CTLA-4-expressing ILC3s restrain interleukin-23-mediated inflammation.
    4. PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice.
      Title: PD-1 or CTLA-4 blockade promotes CD86-driven Treg responses upon radiotherapy of lymphocyte-depleted cancer in mice.
    5. Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity.
      Title: Soluble CTLA-4 attenuates T cell activation and modulates anti-tumor immunity.
    6. IFNgamma and CTLA-4 Drive Hepatic CD4 T-Cell Tolerance and Protection From Autoimmunity in Mice.
      Title: IFNγ and CTLA-4 Drive Hepatic CD4 T-Cell Tolerance and Protection From Autoimmunity in Mice.
    7. DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency.
      Title: DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency.
    8. The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8[+] T-cell immunity.
      Title: The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8(+) T-cell immunity.
    9. CTLA4-Ig alleviates the allogeneic immune responses against insulin-producing cells in a murine model of cell transplantation.
      Title: CTLA4-Ig alleviates the allogeneic immune responses against insulin-producing cells in a murine model of cell transplantation.
    10. CTLA-4 suppresses hapten-induced contact hypersensitivity in atopic dermatitis model mice.
      Title: CTLA-4 suppresses hapten-induced contact hypersensitivity in atopic dermatitis model mice.
    Submit: New GeneRIF Correction See all GeneRIFs (202)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (13) 
    • Targeted (7)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in T cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of B cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of regulatory T cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of regulatory T cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in clathrin-coated endocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of protein complex involved in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytotoxic T-lymphocyte protein 4
    Names
    CD152 antigen
    cytotoxic T-lymphocyte-associated antigen 4

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281976.1 → NP_001268905.1  cytotoxic T-lymphocyte protein 4 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001268905.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks the penultimate coding exon, which results in a frame-shift and early translation termination compared to variant 1. The resulting shorter isoform (2, also known as sCTLA-4) with a distinct C-terminus, lacks the transmembrane domain and is secreted (PMIDs: 10831323, 23400950).
      Source sequence(s)
      AI323635, AK138891, AL663047
      Consensus CDS
      CCDS69893.1
      UniProtKB/TrEMBL
      Q5SSM0
      Related
      ENSMUSP00000095327.4, ENSMUST00000097720.4
      Conserved Domains (2) summary
      cd05721
      Location:39 → 152
      IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
      smart00410
      Location:43 → 132
      IG_like; Immunoglobulin like

    2. NM_009843.4 → NP_033973.2  cytotoxic T-lymphocyte protein 4 isoform 1 precursor

      See identical proteins and their annotated locations for NP_033973.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer membrane-bound isoform (1).
      Source sequence(s)
      AI323635, AK138891, AL663047
      Consensus CDS
      CCDS14993.1
      UniProtKB/Swiss-Prot
      P09793, Q9QZZ7
      UniProtKB/TrEMBL
      Q6GTR6, Q7TMX1
      Related
      ENSMUSP00000027164.3, ENSMUST00000027164.9
      Conserved Domains (2) summary
      cd05721
      Location:39 → 152
      IgV_CTLA-4; Immunoglobulin (Ig) domain of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
      smart00410
      Location:43 → 132
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      60948184..60954991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156357.1 → XP_036012250.1  cytotoxic T-lymphocyte protein 4 isoform X1

      Conserved Domains (2) summary
      cd00096
      Location:1 → 9
      Ig; Ig strand C' [structural motif]
      cl11960
      Location:1 → 73
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P09793.1 GenPept UniProtKB/Swiss-Prot:P09793

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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