Exoc7 exocyst complex component 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Exoc7provided by MGI
Official Full Name: exocyst complex component 7provided by MGI
Primary source: MGI:MGI:1859270
See related: Ensembl:ENSMUSG00000020792 AllianceGenome:MGI:1859270
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Exo70; sec70
Summary: Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within protein transmembrane transport. Located in growth cone membrane. Is expressed in 1-cell stage embryo; primary oocyte; secondary oocyte; and thymus primordium. Orthologous to human EXOC7 (exocyst complex component 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 16.9), CNS E14 (RPKM 16.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 81.11 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (116178823..116197574, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (116287997..116306750, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice.
Title: Deletion of Exoc7, but not Exoc3, in male germ cells causes severe spermatogenesis failure with spermatocyte aggregation in mice.
Insulin-stimulated GLUT4 exocytosis was markedly inhibited in Exoc7 KO adipocytes.
Title: Inducible Exoc7/Exo70 knockout reveals a critical role of the exocyst in insulin-regulated GLUT4 exocytosis.
Here we show that microtubule stabilization, triggered by engagement of the B cell receptor, acts as a cue to release centrosome-associated Exo70, which is redistributed to the immune synapse. This process is coupled to the recruitment and activation of GEF-H1, which is required for assembly of the exocyst complex, used to promote tethering and fusion of lysosomes at the immune synapse.
Title: The exocyst controls lysosome secretion and antigen extraction at the immune synapse of B cells.
Exo70 thus represents a membrane-bending protein that may couple actin dynamics and plasma membrane remodeling for morphogenesis.
Title: Exo70 generates membrane curvature for morphogenesis and cell migration.
fusion of GLUT4 vesicles is the rate-limiting step regulated by insulin downstream of Exo70-mediated tethering
Title: Insulin regulates fusion of GLUT4 vesicles independent of Exo70-mediated tethering.
Results show that Snapin interacts with the exocyst Exo70 and plays a modulatory role in GLUT4 vesicle trafficking.
Title: Snapin interacts with the Exo70 subunit of the exocyst and modulates GLUT4 trafficking.
Given the low level of sequence conservation within Exo70, this structure provides new insights into our understanding of many species-specific functions of the exocyst
Title: The crystal structure of mouse Exo70 reveals unique features of the mammalian exocyst.
The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin
Title: The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin.
Exo70 mediates AMPA receptor insertion at the postsynaptic membrane, but it does not participate in receptor targeting.
Title: Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables phosphatidylinositol-4,5-bisphosphate binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in membrane fission	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic cytokinesis	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of mitotic cytokinetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cytokinetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of entry of bacterium into host cell	IEA Inferred from Electronic Annotation more info
involved_in regulation of entry of bacterium into host cell	ISO Inferred from Sequence Orthology more info
involved_in vesicle docking involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in vesicle tethering involved in exocytosis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
part_of exocyst	IBA Inferred from Biological aspect of Ancestor more info
part_of exocyst	NAS Non-traceable Author Statement more info	PubMed
located_in growth cone membrane	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
is_active_in midbody	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: exocyst complex component 7

Names: exocyst complex component Exo70; exocyst component protein 70 kDa homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001162872.3 → NP_001156344.1 exocyst complex component 7 isoform 2

See identical proteins and their annotated locations for NP_001156344.1

Status: VALIDATED

Source sequence(s)

AL645861

Consensus CDS

CCDS48983.1

UniProtKB/TrEMBL

Q3TIP4, Q542L0, Q7TPT3

Related

ENSMUSP00000102019.4, ENSMUST00000106411.10

Conserved Domains (1) summary

pfam03081
Location:288 → 647

Exo70; Exo70 exocyst complex subunit
NM_001347636.3 → NP_001334565.1 exocyst complex component 7 isoform 3

Status: VALIDATED

Source sequence(s)

AL645861

Consensus CDS

CCDS83935.1

UniProtKB/TrEMBL

A2AAN0, Q3TIP4, Q7TPT3

Related

ENSMUSP00000102021.4, ENSMUST00000106413.10
NM_001362838.2 → NP_001349767.1 exocyst complex component 7 isoform 4

Status: VALIDATED

Source sequence(s)

AL645861

UniProtKB/TrEMBL

Q69ZS4

Conserved Domains (1) summary

pfam03081
Location:342 → 714

Exo70; Exo70 exocyst complex subunit
NM_001362839.2 → NP_001349768.1 exocyst complex component 7 isoform 5

Status: VALIDATED

Source sequence(s)

AL645861

UniProtKB/TrEMBL

Q3TIP4, Q7TPT3

Conserved Domains (1) summary

pfam03081
Location:288 → 660

Exo70; Exo70 exocyst complex subunit
NM_001378960.1 → NP_001365889.1 exocyst complex component 7 isoform 6

Status: VALIDATED

Source sequence(s)

AL645861

UniProtKB/TrEMBL

Q3TIP4, Q7TPT3

Related

ENSMUST00000139699.8

Conserved Domains (1) summary

pfam03081
Location:336 → 701

Exo70; Exo70 exocyst complex subunit
NM_001378961.1 → NP_001365890.1 exocyst complex component 7 isoform 7

Status: VALIDATED

Source sequence(s)

AL645861

UniProtKB/TrEMBL

Q3TIP4, Q7TPT3

Conserved Domains (1) summary

pfam03081
Location:305 → 670

Exo70; Exo70 exocyst complex subunit
NM_016857.4 → NP_058553.2 exocyst complex component 7 isoform 1

See identical proteins and their annotated locations for NP_058553.2

Status: VALIDATED

Source sequence(s)

AL645861

Consensus CDS

CCDS25664.1

UniProtKB/Swiss-Prot

O35250, Q8K121

UniProtKB/TrEMBL

Q3USE0, Q69ZS4

Related

ENSMUSP00000021147.8, ENSMUST00000021147.14

Conserved Domains (1) summary

pfam03081
Location:313 → 691

Exo70; Exo70 exocyst complex subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

116178823..116197574 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533734.4 → XP_006533797.1 exocyst complex component 7 isoform X1

UniProtKB/TrEMBL

Q69ZS4

Conserved Domains (1) summary

pfam03081
Location:305 → 683

Exo70; Exo70 exocyst complex subunit