Prl8a5 prolactin family 8, subfamily A, member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Prl8a5provided by RGD
Official Full Name: prolactin family 8, subfamily A, member 5provided by RGD
Primary source: RGD:708348
See related: EnsemblRapid:ENSRNOG00000043237 AllianceGenome:RGD:708348
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable hormone activity and prolactin receptor binding activity. Involved in female pregnancy. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 17p12

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (37674027..37680240)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (37465641..37471852)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (39411716..39417929)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables prolactin receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IBA Inferred from Biological aspect of Ancestor more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
involved_in mammary gland development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of lactation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to nutrient levels	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: prolactin-8A5

Names: PLP-C; PRL-like protein C; growth hormone-related placental protein 2; placental prolactin-like protein C; prolactin-like protein C related

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173110.2 → NP_775133.2 prolactin-8A5 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A6J7S0, B0BMV3, G3V866

Related

ENSRNOP00000022658.5, ENSRNOT00000022659.10

Conserved Domains (1) summary

pfam00103
Location:17 → 237

Hormone_1; Somatotropin hormone family