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    H2-M10.3 histocompatibility 2, M region locus 10.3 [ Mus musculus (house mouse) ]

    Gene ID: 110696, updated on 9-Dec-2024

    Summary

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    Official Symbol
    H2-M10.3provided by MGI
    Official Full Name
    histocompatibility 2, M region locus 10.3provided by MGI
    Primary source
    MGI:MGI:1276524
    See related
    Ensembl:ENSMUSG00000058124 AllianceGenome:MGI:1276524
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5.3H
    Summary
    Predicted to enable several functions, including beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in several cellular components, including Golgi apparatus; cell surface; and endoplasmic reticulum. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including Stevens-Johnson syndrome; asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to human HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-E (major histocompatibility complex, class I, E). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See H2-M10.3 in Genome Data Viewer
    Location:
    17 B1; 17 19.01 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (36675896..36679309, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36365004..36368417, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42489 Neighboring gene predicted gene, 33257 Neighboring gene histocompatibility 2, M region locus 10.1 Neighboring gene histocompatibility 2, M region locus 10.5, pseudogene 1 Neighboring gene serine/threonine kinase, pseudogene 1 Neighboring gene lectin, galactose binding, soluble 1, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules. Loconto J, et al. Cell, 2003 Mar 7. PMID 12628182
    2. Combinatorial coexpression of neural and immune multigene families in mouse vomeronasal sensory neurons. Ishii T, et al. Curr Biol, 2003 Mar 4. PMID 12620187
    3. Characterization of two class I genes from the H2-M region: evidence for a new subfamily. Arepalli SR, et al. Immunogenetics, 1998. PMID 9435345
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MHC class I protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables T cell receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables TAP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables beta-2-microglobulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables natural killer cell lectin-like receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide antigen binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide antigen binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class Ib IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of T cell mediated cytotoxicity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MHC class I protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MHC class Ib protein complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histocompatibility 2, M region locus 10.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201608.2 → NP_963902.1  histocompatibility 2, M region locus 10.3 precursor

      See identical proteins and their annotated locations for NP_963902.1

      Status: PROVISIONAL

      Source sequence(s)
      AC120403
      Consensus CDS
      CCDS28722.1
      UniProtKB/TrEMBL
      Q85ZW6
      Related
      ENSMUSP00000073236.4, ENSMUST00000073546.5
      Conserved Domains (2) summary
      cd07698
      Location:206 → 298
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:24 → 202
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      36675896..36679309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249449.1 → XP_030105309.1  histocompatibility 2, M region locus 10.3 isoform X1

      Conserved Domains (2) summary
      cd07698
      Location:170 → 262
      IgC_MHC_I_alpha3; Class I major histocompatibility complex (MHC) alpha chain immunoglobulin domain
      cl08246
      Location:33 → 166
      MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
    Nucleotide Protein Strain
    Heading Accession and Version

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