Il4i1 interleukin 4 induced 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il4i1provided by MGI
Official Full Name: interleukin 4 induced 1provided by MGI
Primary source: MGI:MGI:109552
See related: Ensembl:ENSMUSG00000074141 AllianceGenome:MGI:109552
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H4; H-4; H46; LAO; Fig1; H-46; LAAO; mIL4I1; Fig1-ps
Summary: Enables L-amino-acid oxidase activity. Involved in negative regulation of T cell mediated immune response to tumor cell; positive regulation of regulatory T cell differentiation; and regulation of B cell differentiation. Acts upstream of or within aromatic amino acid metabolic process. Located in lysosome. Orthologous to human IL4I1 (interleukin 4 induced 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in spleen adult (RPKM 71.1), testis adult (RPKM 39.3) and 7 other tissues See more
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Genomic context

Location:: 7 B3; 7 28.93 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (44485712..44490233)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (44836288..44840809)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upregulation of IL4-induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties.
Title: Upregulation of IL4-induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties.
L-amino acid oxidase-1 is involved in the gut-liver axis by regulating 5-aminolevulinic acid production in mice.
Title: L-amino acid oxidase-1 is involved in the gut-liver axis by regulating 5-aminolevulinic acid production in mice.
JMJD3 downregulates IL4i1 aggravating lipopolysaccharide-induced acute lung injury via H3K27 and H3K4 demethylation.
Title: JMJD3 downregulates IL4i1 aggravating lipopolysaccharide-induced acute lung injury via H3K27 and H3K4 demethylation.
IL4I1 Accelerates the Expansion of Effector CD8(+) T Cells at the Expense of Memory Precursors by Increasing the Threshold of T-Cell Activation.
Title: IL4I1 Accelerates the Expansion of Effector CD8(+) T Cells at the Expense of Memory Precursors by Increasing the Threshold of T-Cell Activation.
IL4I1 negatively controls B-Cell Antigen Receptor-dependent B cell activation.
Title: IL-4-Induced Gene 1: A Negative Immune Checkpoint Controlling B Cell Differentiation and Activation.
The H46 locus on chromosome 7 was found to encode the interleukin 4-induced IL4i1 gene.
Title: Second class minors: molecular identification of the autosomal H46 histocompatibility locus as a peptide presented by major histocompatibility complex class II molecules.
IL4I1 promotes central nervous system remyelination and axonal integrity.
Title: IL4I1 augments CNS remyelination and axonal protection by modulating T cell driven inflammation.
our findings indicate that IL4I1 promotes an enhanced M2 functional phenotype.
Title: IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production.
inhibits CD8+ antitumor T-cell response in vivo
Title: IL4I1: an inhibitor of the CD8⁺ antitumor T-cell response in vivo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6)
Not Applicable (2) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

Fig1 (e-PCR), detects polymorphism
- UniSTS:143108

U70429 (e-PCR)
- UniSTS:179563

Readthrough Il4i1b

Readthrough gene: Il4i1b, Included gene: Nup62

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables L-amino-acid oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-amino-acid oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables L-amino-acid oxidase activity	ISO Inferred from Sequence Orthology more info
enables L-phenylalaine oxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in L-phenylalanine catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in amino acid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within aromatic amino acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell activation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of T cell mediated immune response to tumor cell	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of T cell mediated immune response to tumor cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of T cell mediated immune response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of regulatory T cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of adaptive immune response	ISO Inferred from Sequence Orthology more info
involved_in regulation of adaptive immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in tryptophan catabolic process	ISO Inferred from Sequence Orthology more info
involved_in tryptophan catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in tryptophan catabolic process to indole-3-acetate	ISO Inferred from Sequence Orthology more info
involved_in tryptophan catabolic process to indole-3-acetate	ISS Inferred from Sequence or Structural Similarity more info
involved_in tyrosine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in tyrosine catabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in acrosomal vesicle	ISO Inferred from Sequence Orthology more info
located_in acrosomal vesicle	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
located_in immunological synapse	ISS Inferred from Sequence or Structural Similarity more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: L-amino-acid oxidase

Names: IL4-induced protein 1; histocompatibility 46; interleukin-4-induced protein 1; interleukin-four induced gene 1; interleukin-four induced gene-1 protein; interleukin-four induced protein-1; protein Fig-1

NP_034345.2

EC 1.4.3.2

EC 1.4.3.25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.