Kif15 kinesin family member 15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif15provided by MGI
Official Full Name: kinesin family member 15provided by MGI
Primary source: MGI:MGI:1098258
See related: Ensembl:ENSMUSG00000036768 AllianceGenome:MGI:1098258
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: HKLP2; Knsl7; D330038N01; b2b1117.1Clo; 3110023M17Rik; 3930402I10Rik; b2b1117.1aClo
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in centrosome separation; microtubule-based movement; and mitotic spindle assembly. Predicted to be located in spindle pole. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human KIF15 (kinesin family member 15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E11.5 (RPKM 16.2), liver E14 (RPKM 10.9) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F4; 9 73.31 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (122780146..122847798)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (122951081..123018733)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kif15 deficiency contributes to depression-like behavior in mice.
Title: Kif15 deficiency contributes to depression-like behavior in mice.
Deficiency of Kif15 gene inhibits tumor growth due to host CD8[+]T lymphocytes increase.
Title: Deficiency of Kif15 gene inhibits tumor growth due to host CD8(+)T lymphocytes increase.
Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis.
Title: Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis.
Kif15 opposes the capacity of other motors to generate independent microtubule movements within key regions of developing neurons.
Title: Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kif15 (e-PCR), detects polymorphism
- UniSTS:527399

Kif15 (e-PCR), detects polymorphism
- UniSTS:507008

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in centrosome separation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule-based movement	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: kinesin-like protein KIF15

Names: N-10 kinesin; kinesin 15; kinesin-like 7; kinesin-like protein 2; kinesin-like protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010620.1 → NP_034750.1 kinesin-like protein KIF15

See identical proteins and their annotated locations for NP_034750.1

Status: PROVISIONAL

Source sequence(s)

BC060710

Consensus CDS

CCDS23651.1

UniProtKB/Swiss-Prot

O35065, Q6P9L6, Q70MX5

Related

ENSMUSP00000035490.6, ENSMUST00000040717.7

Conserved Domains (5) summary

smart00129
Location:26 → 370

KISc; Kinesin motor, catalytic domain. ATPase

TIGR02168
Location:520 → 1339

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

cd01373
Location:25 → 373

KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup

pfam12711
Location:463 → 551

Kinesin-relat_1; Kinesin motor

pfam15908
Location:1267 → 1387

HMMR_C; Hyaluronan mediated motility receptor C-terminal