Lactb lactamase, beta [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lactbprovided by MGI
Official Full Name: lactamase, betaprovided by MGI
Primary source: MGI:MGI:1933395
See related: Ensembl:ENSMUSG00000032370 AllianceGenome:MGI:1933395
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lact1; LACT-1; Mrpl56
Summary: Predicted to enable identical protein binding activity and peptidase activity. Predicted to be involved in proteolysis and regulation of lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human LACTB (lactamase beta). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 13.5), adrenal adult (RPKM 10.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 C; 9 36.23 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (66862668..66882706, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (66955382..66975484, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that miRNA-351-5p functions in skeletal myogenesis by targeting LACTB and is regulated by lnc-mg, supporting the role of the competing endogenous RNA network in skeletal myogenesis.
Title: MicroRNA-351-5p mediates skeletal myogenesis by directly targeting lactamase-β and is regulated by lnc-mg.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine beta-lactamase-like protein LACTB, mitochondrial

Names: mitochondrial ribosomal protein L56; serine beta lactamase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411305.1 → NP_001398234.1 serine beta-lactamase-like protein LACTB, mitochondrial isoform 2

Status: VALIDATED

Source sequence(s)

AC159741, AC166370

UniProtKB/TrEMBL

A0A1L1SVF9

Related

ENSMUSP00000151155.2, ENSMUST00000215172.2
NM_030717.2 → NP_109642.1 serine beta-lactamase-like protein LACTB, mitochondrial isoform 1 precursor

See identical proteins and their annotated locations for NP_109642.1

Status: VALIDATED

Source sequence(s)

AC159741, AC166370

Consensus CDS

CCDS40674.1

UniProtKB/Swiss-Prot

Q9EP89

UniProtKB/TrEMBL

B2RWI2, Q80UJ8

Related

ENSMUSP00000034929.7, ENSMUST00000034929.7

Conserved Domains (2) summary

pfam00144
Location:110 → 528

Beta-lactamase; Beta-lactamase

pfam06459
Location:224 → 303

RR_TM4-6; Ryanodine Receptor TM 4-6