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    Magea4 MAGE family member A4 [ Mus musculus (house mouse) ]

    Gene ID: 17140, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Magea4provided by MGI
    Official Full Name
    MAGE family member A4provided by MGI
    Primary source
    MGI:MGI:1333839
    See related
    Ensembl:ENSMUSG00000033343 AllianceGenome:MGI:1333839
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mage-a4
    Summary
    Predicted to enable DNA-binding transcription factor binding activity; histone deacetylase binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in PML body and cytosol. Predicted to be active in nucleus. Is expressed in several structures, including brain; egg cylinder; gonad; heart; and liver. Orthologous to several human genes including MAGEA10 (MAGE family member A10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Magea4 in Genome Data Viewer
    Location:
    X A7.3; X 37.2 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (71264599..71266611)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (72221015..72222964)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide gated channel alpha 2 Neighboring gene STARR-seq mESC enhancer starr_47328 Neighboring gene STARR-seq mESC enhancer starr_47329 Neighboring gene STARR-seq mESC enhancer starr_47330 Neighboring gene STARR-seq mESC enhancer starr_47331 Neighboring gene STARR-seq mESC enhancer starr_47332 Neighboring gene predicted gene, 39519 Neighboring gene STARR-seq mESC enhancer starr_47333 Neighboring gene gamma-aminobutyric acid (GABA) A receptor, subunit epsilon Neighboring gene microRNA 224 Neighboring gene microRNA 452

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells. Sakurai T, et al. J Biol Chem, 2004 Apr 9. PMID 14739298
    2. MAGE cancer-testis antigens protect the mammalian germline under environmental stress. Fon Tacer K, et al. Sci Adv, 2019 May. PMID 31149633, Free PMC Article
    3. A new family of mouse genes homologous to the human MAGE genes. De Plaen E, et al. Genomics, 1999 Jan 15. PMID 9933564
    4. Expression dynamics of Mage family genes during self-renewal and differentiation of mouse pluripotent stem and teratocarcinoma cells. Gordeeva O, et al. Oncotarget, 2019 May 14. PMID 31143371, Free PMC Article
    5. An overview of the MAGE gene family with the identification of all human members of the family. Chomez P, et al. Cancer Res, 2001 Jul 15. PMID 11454705

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis
      Title: A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC123681, MGC123682

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    melanoma-associated antigen 4
    Names
    melanoma antigen, family A, 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020280.3 → NP_064676.2  melanoma-associated antigen 4

      See identical proteins and their annotated locations for NP_064676.2

      Status: VALIDATED

      Source sequence(s)
      AL671874
      Consensus CDS
      CCDS30185.1
      UniProtKB/TrEMBL
      F2Z493, Q3SXV1
      Related
      ENSMUSP00000046715.2, ENSMUST00000048675.2
      Conserved Domains (2) summary
      pfam01454
      Location:161 → 271
      MAGE; MAGE family
      pfam12440
      Location:16 → 84
      MAGE_N; Melanoma associated antigen family N terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      71264599..71266611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011247539.2 → XP_011245841.1  melanoma-associated antigen 4 isoform X1

      Conserved Domains (2) summary
      pfam01454
      Location:161 → 271
      MAGE; MAGE family
      pfam12440
      Location:16 → 84
      MAGE_N; Melanoma associated antigen family N terminal
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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