U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Gnptg N-acetylglucosamine-1-phosphate transferase subunit gamma [ Rattus norvegicus (Norway rat) ]

    Gene ID: 287134, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Gnptgprovided by RGD
    Official Full Name
    N-acetylglucosamine-1-phosphate transferase subunit gammaprovided by RGD
    Primary source
    RGD:1311614
    See related
    AllianceGenome:RGD:1311614
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gnptag
    Summary
    Contributes to UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity. Predicted to be involved in carbohydrate phosphorylation. Located in Golgi membrane. Human ortholog(s) of this gene implicated in glycoproteinosis and mucolipidosis III gamma. Orthologous to human GNPTG (N-acetylglucosamine-1-phosphate transferase subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 172.0), Brain (RPKM 147.8) and 9 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Gnptg in Genome Data Viewer
    Location:
    10q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14756685..14761636, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (14252186..14257128, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14593050..14597995, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095050 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 4 Neighboring gene unk like zinc finger Neighboring gene TSR3 ribosome maturation factor Neighboring gene BAI1-associated protein 3 Neighboring gene microRNA 3547

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Identification of UDP-N-acetylglucosamine-phosphotransferase-binding sites on the lysosomal proteases, cathepsins A, B, and D. Lukong KE, et al. Biochemistry, 1999 Jan 5. PMID 9890884
    2. Lysosomal enzyme phosphorylation. Recognition of a protein-dependent determinant allows specific phosphorylation of oligosaccharides present on lysosomal enzymes. Lang L, et al. J Biol Chem, 1984 Dec 10. PMID 6094568
    3. Lysosomal-enzyme targeting: the phosphorylation of synthetic D-mannosyl saccharides by UDP-N-acetyl-glucosamine:lysosomal-enzyme N-acetylglucosamine-phosphotransferase from rat-liver microsomes and fibroblasts. Madiyalakan R, et al. Carbohydr Res, 1986 Sep 1. PMID 3021329
    4. Post-translational modifications of the gamma-subunit affect intracellular trafficking and complex assembly of GlcNAc-1-phosphotransferase. Encarnação M, et al. J Biol Chem, 2011 Feb 18. PMID 21173149, Free PMC Article
    5. Molecular basis of variant pseudo-hurler polydystrophy (mucolipidosis IIIC). Raas-Rothschild A, et al. J Clin Invest, 2000 Mar. PMID 10712439, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    N-acetylglucosamine-1-phosphotransferase subunit gamma
    Names
    N-acetylglucosamine-1-phosphate transferase, gamma subunit
    N-acetylglucosamine-1-phosphotransferase, gamma subunit

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100493.1 → NP_001093963.1  N-acetylglucosamine-1-phosphotransferase subunit gamma precursor

      See identical proteins and their annotated locations for NP_001093963.1

      Status: PROVISIONAL

      Source sequence(s)
      BC158818
      UniProtKB/TrEMBL
      A0A9K3Y7E8, B0BNH1, F1LML8, Q4G066
      Conserved Domains (1) summary
      pfam07915
      Location:69 → 129
      PRKCSH; Glucosidase II beta subunit-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      14756685..14761636 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245935.5 → XP_006245997.1  N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X1

      UniProtKB/TrEMBL
      Q4G066
      Conserved Domains (2) summary
      pfam06464
      Location:178 → 261
      DMAP_binding; DMAP1-binding Domain
      pfam07915
      Location:69 → 129
      PRKCSH; Glucosidase II beta subunit-like protein

    2. XM_063268567.1 → XP_063124637.1  N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X2

    3. XM_063268568.1 → XP_063124638.1  N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X2

    4. XM_039085361.2 → XP_038941289.1  N-acetylglucosamine-1-phosphotransferase subunit gamma isoform X2

      Conserved Domains (1) summary
      cl06793
      Location:5 → 54
      PRKCSH; Glucosidase II beta subunit-like protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools