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    Dhrs3 dehydrogenase/reductase 3 [ Mus musculus (house mouse) ]

    Gene ID: 20148, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dhrs3provided by MGI
    Official Full Name
    dehydrogenase/reductase 3provided by MGI
    Primary source
    MGI:MGI:1315215
    See related
    Ensembl:ENSMUSG00000066026 AllianceGenome:MGI:1315215
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rsdr1; retSDR1
    Summary
    Enables all-trans-retinol dehydrogenase (NAD+) activity. Acts upstream of or within several processes, including heart morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be located in membrane. Predicted to be active in lipid droplet. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human DHRS3 (dehydrogenase/reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in kidney adult (RPKM 53.4), bladder adult (RPKM 42.8) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dhrs3 in Genome Data Viewer
    Location:
    4 E1; 4 78.14 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (144618712..144654214)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (144892534..144928209)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11990 Neighboring gene STARR-seq mESC enhancer starr_11991 Neighboring gene peroxiredoxin 2, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_11992 Neighboring gene predicted gene, 46890 Neighboring gene STARR-seq mESC enhancer starr_11993 Neighboring gene STARR-positive B cell enhancer ABC_E8006 Neighboring gene STARR-positive B cell enhancer ABC_E10275 Neighboring gene vacuolar protein sorting 13D Neighboring gene predicted gene, 42344 Neighboring gene predicted gene, 36317

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. Haeseleer F, et al. J Biol Chem, 1998 Aug 21. PMID 9705317
    2. Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes. Klyuyeva AV, et al. J Biol Chem, 2021 Jan-Jun. PMID 33485967, Free PMC Article
    3. p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation. Deisenroth C, et al. J Biol Chem, 2011 Aug 12. PMID 21659514, Free PMC Article
    4. Alterations in retinoic acid signaling affect the development of the mouse coronary vasculature. Wang S, et al. Dev Dyn, 2018 Aug. PMID 29806219, Free PMC Article
    5. Bmp-2 downstream targets in mesenchymal development identified by subtractive cloning from recombinant mesenchymal progenitors (C3H10T1/2). Bächner D, et al. Dev Dyn, 1998 Dec. PMID 9853961

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
      Title: Changes in retinoid metabolism and signaling associated with metabolic remodeling during fasting and in type I diabetes.
    2. Epicardial upregulation of DHRS3 gene Results in Defective Coronary Vessel Development.
      Title: Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development.
    3. Yap targets Dhrs3, to reduce retinoic acid synthesis and inhibit cardiac fibroblast differentiation during development.
      Title: Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development.
    4. Dhrs3 plays critical roles in the development of the heart and the coronary vasculature by controlling the formation of retinoic acid.
      Title: Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells.
    5. DHRS3 is important in limiting the formation of retinoic acid to ensure the proper development of the coronary vasculature.
      Title: Retinoic acid signaling promotes the cytoskeletal rearrangement of embryonic epicardial cells.
    6. DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. Lack of DHRS3 leads to increases in the levels of retinoic acid, decreases in the levels of retinol and retinyl esters and changes in the expression of genes regulated by retinoic acid. As a result, Dhrs3-deficient embryos exhibit defects in the development of the heart, palate and skeleton and are not viable.
      Title: The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development.
    7. Reduction of retinaldehyde by DHRS3 is critical for preventing formation of excess ATRA during embryonic development.
      Title: The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development.
    8. p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation.
      Title: p53-Inducible DHRS3 is an endoplasmic reticulum protein associated with lipid droplet accumulation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables all-trans-retinol dehydrogenase (NAD+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables all-trans-retinol dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables all-trans-retinol dehydrogenase (NADP+) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac septum morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within outflow tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of retinoic acid receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinoid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within retinoid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within roof of mouth development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    short-chain dehydrogenase/reductase 3
    Names
    dehydrogenase/reductase (SDR family) member 3
    retinal short-chain dehydrogenase/reductase 1
    NP_001165895.1
    NP_001344203.1
    NP_001344204.2
    NP_001344205.2
    NP_001344206.1
    NP_001411778.1
    NP_001411779.1
    NP_001411780.1
    NP_001411781.1
    NP_035433.1
    XP_006538744.1
    XP_030109228.1
    XP_036019818.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172424.3 → NP_001165895.1  short-chain dehydrogenase/reductase 3 isoform 2

      See identical proteins and their annotated locations for NP_001165895.1

      Status: VALIDATED

      Source sequence(s)
      AL606909, AL626773
      Consensus CDS
      CCDS51368.1
      UniProtKB/TrEMBL
      G5E8W9
      Related
      ENSMUSP00000126154.2, ENSMUST00000171001.8
      Conserved Domains (1) summary
      cd05339
      Location:27 → 255
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

    2. NM_001357274.2 → NP_001344203.1  short-chain dehydrogenase/reductase 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL606909, AL626773
      Consensus CDS
      CCDS51368.1
      UniProtKB/TrEMBL
      G5E8W9
      Conserved Domains (1) summary
      cd05339
      Location:27 → 255
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

    3. NM_001357275.2 → NP_001344204.2  short-chain dehydrogenase/reductase 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606909, AL626773

    4. NM_001357276.2 → NP_001344205.2  short-chain dehydrogenase/reductase 3 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL606909, AL626773

    5. NM_001357277.2 → NP_001344206.1  short-chain dehydrogenase/reductase 3 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL606909, AL626773
      Conserved Domains (1) summary
      cd05339
      Location:1 → 196
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

    6. NM_001424849.1 → NP_001411778.1  short-chain dehydrogenase/reductase 3 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL606909, AL626773

    7. NM_001424850.1 → NP_001411779.1  short-chain dehydrogenase/reductase 3 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL606909, AL626773

    8. NM_001424851.1 → NP_001411780.1  short-chain dehydrogenase/reductase 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL606909, AL626773

    9. NM_001424852.1 → NP_001411781.1  short-chain dehydrogenase/reductase 3 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL606909, AL626773
      Related
      ENSMUSP00000101370.2, ENSMUST00000105744.8

    10. NM_011303.8 → NP_035433.1  short-chain dehydrogenase/reductase 3 isoform 1

      See identical proteins and their annotated locations for NP_035433.1

      Status: VALIDATED

      Source sequence(s)
      AL606909, AL626773
      Consensus CDS
      CCDS18912.1
      UniProtKB/Swiss-Prot
      O88876, Q3UAD1, Q91WR0, Q91XC3, Q922A6
      Related
      ENSMUSP00000122552.2, ENSMUST00000154208.8
      Conserved Domains (2) summary
      cd05339
      Location:53 → 281
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
      PRK09072
      Location:35 → 288
      PRK09072; short chain dehydrogenase; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      144618712..144654214
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253368.2 → XP_030109228.1  short-chain dehydrogenase/reductase 3 isoform X2

      Conserved Domains (1) summary
      cd05339
      Location:48 → 216
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

    2. XM_006538681.5 → XP_006538744.1  short-chain dehydrogenase/reductase 3 isoform X2

      See identical proteins and their annotated locations for XP_006538744.1

      Conserved Domains (1) summary
      cd05339
      Location:48 → 216
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

    3. XM_036163925.1 → XP_036019818.1  short-chain dehydrogenase/reductase 3 isoform X1

      Conserved Domains (1) summary
      cd05339
      Location:53 → 233
      17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88876.2 GenPept UniProtKB/Swiss-Prot:O88876

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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