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    Sgsm3 small G protein signaling modulator 3 [ Mus musculus (house mouse) ]

    Gene ID: 105835, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sgsm3provided by MGI
    Official Full Name
    small G protein signaling modulator 3provided by MGI
    Primary source
    MGI:MGI:1916329
    See related
    Ensembl:ENSMUSG00000042303 AllianceGenome:MGI:1916329
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cip85; RUSC3; Rutbc3; 1810012I01Rik
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in positive regulation of protein catabolic process. Located in gap junction. Is expressed in several structures, including central nervous system; ganglia; genitourinary system; lung; and submandibular gland primordium. Orthologous to human SGSM3 (small G protein signaling modulator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 44.3), testis adult (RPKM 20.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sgsm3 in Genome Data Viewer
    Location:
    15 E1; 15 37.96 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (80861966..80896491)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (80977762..81012290)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene trinucleotide repeat containing 6b Neighboring gene STARR-seq mESC enhancer starr_39246 Neighboring gene microRNA 5113 Neighboring gene predicted gene 6612 Neighboring gene adenylosuccinate lyase Neighboring gene STARR-seq mESC enhancer starr_39247 Neighboring gene predicted gene, 31462 Neighboring gene myocardin related transcription factor A Neighboring gene predicted gene, 25131 Neighboring gene STARR-seq mESC enhancer starr_39250 Neighboring gene RIKEN cDNA 4930483J18 gene Neighboring gene STARR-positive B cell enhancer ABC_E943

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Small G protein signaling modulator 3 (SGSM3) knockdown attenuates apoptosis and cardiogenic differentiation in rat mesenchymal stem cells exposed to hypoxia. Jung SE, et al. PLoS One, 2020. PMID 32271805, Free PMC Article
    2. Novel rab GAP-like protein, CIP85, interacts with connexin43 and induces its degradation. Lan Z, et al. Biochemistry, 2005 Feb 22. PMID 15709751, Free PMC Article
    3. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. Yang H, et al. Genomics, 2007 Aug. PMID 17509819
    4. Screening for target Rabs of TBC (Tre-2/Bub2/Cdc16) domain-containing proteins based on their Rab-binding activity. Itoh T, et al. Genes Cells, 2006 Sep. PMID 16923123
    5. RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse. Hüttenhofer A, et al. EMBO J, 2001 Jun 1. PMID 11387227, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables GTPase regulator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in plasma membrane to endosome transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in plasma membrane to endosome transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of Rab protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in gap junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    small G protein signaling modulator 3
    Names
    Cx43-interacting protein of 85-kDa
    RUN and TBC1 domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357669.1 → NP_001344598.1  small G protein signaling modulator 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC141880
      UniProtKB/TrEMBL
      A0A2R8VI76
      Conserved Domains (3) summary
      cd11813
      Location:409 → 461
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:114 → 320
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:488 → 639
      RUN; RUN domain

    2. NM_134091.2 → NP_598852.3  small G protein signaling modulator 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AI844026, AK142314, BC018197, BY242851
      Consensus CDS
      CCDS49673.2
      UniProtKB/Swiss-Prot
      Q3TCB6, Q8VCZ6
      UniProtKB/TrEMBL
      A0A2R8VI76
      Related
      ENSMUSP00000122543.2, ENSMUST00000139517.9
      Conserved Domains (3) summary
      cd11813
      Location:484 → 536
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:114 → 325
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:563 → 717
      RUN; RUN domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      80861966..80896491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006520249.5 → XP_006520312.1  small G protein signaling modulator 3 isoform X3

      UniProtKB/TrEMBL
      A0A2R8VI76
      Conserved Domains (3) summary
      cd11813
      Location:495 → 547
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:125 → 336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:574 → 725
      RUN; RUN domain

    2. XM_006520244.5 → XP_006520307.1  small G protein signaling modulator 3 isoform X1

      See identical proteins and their annotated locations for XP_006520307.1

      UniProtKB/TrEMBL
      A0A2R8VI76
      Conserved Domains (3) summary
      cd11813
      Location:495 → 547
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:125 → 336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:574 → 725
      RUN; RUN domain

    3. XM_030248261.2 → XP_030104121.1  small G protein signaling modulator 3 isoform X4

      UniProtKB/TrEMBL
      A0A2R8VI76
      Conserved Domains (3) summary
      cd11813
      Location:494 → 546
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:124 → 335
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:573 → 724
      RUN; RUN domain

    4. XM_017316358.3 → XP_017171847.1  small G protein signaling modulator 3 isoform X5

      UniProtKB/TrEMBL
      A0A2R8VI76
      Conserved Domains (3) summary
      cd11813
      Location:318 → 370
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      pfam00566
      Location:11 → 159
      RabGAP-TBC; Rab-GTPase-TBC domain
      pfam02759
      Location:397 → 548
      RUN; RUN domain

    5. XM_006520245.5 → XP_006520308.1  small G protein signaling modulator 3 isoform X1

      See identical proteins and their annotated locations for XP_006520308.1

      UniProtKB/TrEMBL
      A0A2R8VI76
      Conserved Domains (3) summary
      cd11813
      Location:495 → 547
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:125 → 336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:574 → 725
      RUN; RUN domain

    6. XM_006520247.5 → XP_006520310.1  small G protein signaling modulator 3 isoform X2

      See identical proteins and their annotated locations for XP_006520310.1

      UniProtKB/TrEMBL
      A0A2R8VI76
      Related
      ENSMUSP00000155794.2, ENSMUST00000124845.9
      Conserved Domains (3) summary
      cd11813
      Location:494 → 546
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:124 → 335
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:573 → 724
      RUN; RUN domain

    7. XM_006520246.5 → XP_006520309.1  small G protein signaling modulator 3 isoform X1

      See identical proteins and their annotated locations for XP_006520309.1

      UniProtKB/TrEMBL
      A0A2R8VI76
      Conserved Domains (3) summary
      cd11813
      Location:495 → 547
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:125 → 336
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:574 → 725
      RUN; RUN domain

    8. XM_006520248.5 → XP_006520311.1  small G protein signaling modulator 3 isoform X2

      See identical proteins and their annotated locations for XP_006520311.1

      UniProtKB/TrEMBL
      A0A2R8VI76
      Conserved Domains (3) summary
      cd11813
      Location:494 → 546
      SH3_SGSM3; Src Homology 3 domain of Small G protein Signaling Modulator 3
      smart00164
      Location:124 → 335
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam02759
      Location:573 → 724
      RUN; RUN domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCZ6.1 GenPept UniProtKB/Swiss-Prot:Q8VCZ6

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