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    Txndc8 thioredoxin domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 67402, updated on 10-Dec-2024

    Summary

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    Official Symbol
    Txndc8provided by MGI
    Official Full Name
    thioredoxin domain containing 8provided by MGI
    Primary source
    MGI:MGI:1914652
    See related
    Ensembl:ENSMUSG00000038709 AllianceGenome:MGI:1914652
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Trx6; Sptrx3; Sptrx-3; 4930429J24Rik
    Summary
    Predicted to be involved in spermatogenesis. Located in Golgi apparatus and acrosomal vesicle. Orthologous to human TXNDC8 (thioredoxin domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 107.7) See more
    Orthologs
    human all
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    Genomic context

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    See Txndc8 in Genome Data Viewer
    Location:
    4 B3; 4 31.87 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (57984029..58009126, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (57984021..58009135, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2113 Neighboring gene thioredoxin 1 Neighboring gene predicted gene, 35344 Neighboring gene STARR-seq mESC enhancer starr_10354 Neighboring gene predicted gene, 35402 Neighboring gene sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_10355 Neighboring gene predicted gene, 30907

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Absolute mRNA levels and transcriptional regulation of the mouse testis-specific thioredoxins. Jiménez A, et al. Biochem Biophys Res Commun, 2005 Apr 29. PMID 15781233
    2. Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis. Jiménez A, et al. J Biol Chem, 2004 Aug 13. PMID 15181017
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SPTRX3 is a novel Golgi apparatus-associated thioredoxin, and has a role in aberrant spermatogenesis [SPTRX-3]
      Title: Spermatocyte/spermatid-specific thioredoxin-3, a novel Golgi apparatus-associated thioredoxin, is a specific marker of aberrant spermatogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC151140, MGC151142

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    thioredoxin domain-containing protein 8
    Names
    spermatid-specific thioredoxin-3
    thioredoxin-6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001416052.1 → NP_001402981.1  thioredoxin domain-containing protein 8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL929406

    2. NM_001416053.1 → NP_001402982.1  thioredoxin domain-containing protein 8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL929406

    3. NM_026132.3 → NP_080408.3  thioredoxin domain-containing protein 8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL929406
      Consensus CDS
      CCDS18208.1
      UniProtKB/Swiss-Prot
      Q69AB2, Q78Y03, Q80YE0, Q9CQ96
      UniProtKB/TrEMBL
      Q14AP0
      Related
      ENSMUSP00000099961.5, ENSMUST00000102897.11
      Conserved Domains (1) summary
      cd02947
      Location:9 → 81
      TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      57984029..58009126 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q69AB2.1 GenPept UniProtKB/Swiss-Prot:Q69AB2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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