Zfp28 zinc finger protein 28 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp28provided by MGI
Official Full Name: zinc finger protein 28provided by MGI
Primary source: MGI:MGI:99175
See related: Ensembl:ENSMUSG00000062861 AllianceGenome:MGI:99175
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mkr-5; Zfp-28; 2810438M17Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; and genitourinary system. Orthologous to human ZFP28 (ZFP28 zinc finger protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E18 (RPKM 4.3), CNS E14 (RPKM 3.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 3.7 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (6386317..6399636)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (6383206..6396637)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these results suggest that murine and human Zfp28/ZFP28 is correlated with the pathogenesis of melanoma.
Title: Zinc finger protein 28 as a novel melanoma-related molecule.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Zfp28 (e-PCR), detects polymorphism
- UniSTS:144825

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 28

Names: protein mKR5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175247.3 → NP_780456.2 zinc finger protein 28

See identical proteins and their annotated locations for NP_780456.2

Status: VALIDATED

Source sequence(s)

AK173170, AW488938, BY011080

Consensus CDS

CCDS39752.1

UniProtKB/Swiss-Prot

P10078, Q61776, Q8BT11, Q8C836

Related

ENSMUSP00000079812.8, ENSMUST00000081022.9

Conserved Domains (4) summary

smart00349
Location:103 → 163

KRAB; krueppel associated box

COG5048
Location:341 → 763

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:576 → 596

ZF_C2H2; C2H2 Zn finger [structural motif]

cl02581
Location:243 → 281

KRAB_A-box; KRAB (Kruppel-associated box) domain -A box