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    Marchf8 membrane associated ring-CH-type finger 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312656, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Marchf8provided by RGD
    Official Full Name
    membrane associated ring-CH-type finger 8provided by RGD
    Primary source
    RGD:1309339
    See related
    EnsemblRapid:ENSRNOG00000012297 AllianceGenome:RGD:1309339
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mir; March8
    Summary
    Predicted to enable MHC class II protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including antigen processing and presentation of peptide antigen via MHC class II; negative regulation of MHC class II biosynthetic process; and protein polyubiquitination. Predicted to be located in endosome. Predicted to be active in early endosome membrane; late endosome membrane; and lysosome. Orthologous to human MARCHF8 (membrane associated ring-CH-type finger 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 204.9), Liver (RPKM 163.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Marchf8 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (151086076..151203205)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (149415642..149530771)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (148285467..148398148)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene WASH complex subunit 2C Neighboring gene ribosomal protein L9, pseudogene 19 Neighboring gene zinc finger AN1-type containing 4 Neighboring gene ribosomal protein L23A like 6 Neighboring gene arachidonate 5-lipoxygenase Neighboring gene transfer RNA proline (anticodon GGG) 3 Neighboring gene olfactory receptor family 13 subfamily A member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Inhibition of MHC class II expression and immune responses by c-MIR. Ohmura-Hoshino M, et al. J Immunol, 2006 Jul 1. PMID 16785530
    2. The HLA-DRalpha chain is modified by polyubiquitination. Lapaque N, et al. J Biol Chem, 2009 Mar 13. PMID 19117940, Free PMC Article
    3. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. Bartee E, et al. J Virol, 2004 Feb. PMID 14722266, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables MHC class II protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables MHC protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in antigen processing and presentation of peptide antigen via MHC class II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of MHC class II biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF8
    Names
    E3 ubiquitin-protein ligase MARCH8
    c-mir, cellular modulator of immune recognition
    membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
    NP_001101352.1
    NP_001388595.1
    NP_001388603.1
    XP_017448134.1
    XP_017448136.1
    XP_038963572.1
    XP_038963573.1
    XP_063142173.1
    XP_063142174.1
    XP_063142175.1
    XP_063142176.1
    XP_063142177.1
    XP_063142178.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107882.2 → NP_001101352.1  E3 ubiquitin-protein ligase MARCHF8 isoform 1

      See identical proteins and their annotated locations for NP_001101352.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IL15, D3ZG81
      Related
      ENSRNOP00000017294.2, ENSRNOT00000017294.6
      Conserved Domains (1) summary
      cd16698
      Location:75 → 126
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    2. NM_001401666.1 → NP_001388595.1  E3 ubiquitin-protein ligase MARCHF8 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IL15, D3ZG81

    3. NM_001401674.1 → NP_001388603.1  E3 ubiquitin-protein ligase MARCHF8 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0U1RS36
      Related
      ENSRNOP00000075920.2, ENSRNOT00000092294.3
      Conserved Domains (1) summary
      cd16807
      Location:352 → 414
      RING_CH-C4HC3_MARCH8; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH8 (MARCH8)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      151086076..151203205
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107644.2 → XP_038963572.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RS36
      Conserved Domains (1) summary
      cd16807
      Location:352 → 414
      RING_CH-C4HC3_MARCH8; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH8 (MARCH8)

    2. XM_063286106.1 → XP_063142176.1  E3 ubiquitin-protein ligase MARCHF8 isoform X3

      UniProtKB/TrEMBL
      A6IL15, D3ZG81

    3. XM_063286103.1 → XP_063142173.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RS36

    4. XM_017592647.3 → XP_017448136.1  E3 ubiquitin-protein ligase MARCHF8 isoform X2

      Conserved Domains (1) summary
      cd16698
      Location:318 → 369
      RING_CH-C4HC3_MARCH1_like; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING finger protein MARCH1, MARCH8, and similar proteins

    5. XM_039107645.2 → XP_038963573.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RS36
      Conserved Domains (1) summary
      cd16807
      Location:352 → 414
      RING_CH-C4HC3_MARCH8; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH8 (MARCH8)

    6. XM_063286105.1 → XP_063142175.1  E3 ubiquitin-protein ligase MARCHF8 isoform X2

      Related
      ENSRNOP00000105630.1, ENSRNOT00000167151.1

    7. XM_063286104.1 → XP_063142174.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RS36

    8. XM_063286108.1 → XP_063142178.1  E3 ubiquitin-protein ligase MARCHF8 isoform X3

      UniProtKB/TrEMBL
      A6IL15, D3ZG81

    9. XM_017592645.3 → XP_017448134.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      UniProtKB/TrEMBL
      A0A0U1RS36
      Conserved Domains (1) summary
      cd16807
      Location:352 → 414
      RING_CH-C4HC3_MARCH8; RING-CH finger, H2 subclass (C4HC3-type), found in membrane-associated RING-CH8 (MARCH8)

    10. XM_063286107.1 → XP_063142177.1  E3 ubiquitin-protein ligase MARCHF8 isoform X3

      UniProtKB/TrEMBL
      A6IL15, D3ZG81
    Nucleotide Protein Strain
    Heading Accession and Version

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