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    Pnrc1 proline-rich nuclear receptor coactivator 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286988, updated on 9-Dec-2024

    Summary

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    Symbol
    Pnrc1provided by RGD
    Full Name
    proline-rich nuclear receptor coactivator 1provided by RGD
    Primary source
    RGD:628753
    See related
    EnsemblRapid:ENSRNOG00000007793 AllianceGenome:RGD:628753
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Prol2
    Summary
    Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to be active in P-body and nucleus. Orthologous to human PNRC1 (proline rich nuclear receptor coactivator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 477.5), Spleen (RPKM 337.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pnrc1 in Genome Data Viewer
    Location:
    5q21
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (52443400..52489303, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (47647070..47657832, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (48501472..48504511, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene peptidase M20 domain containing 2 Neighboring gene serine and arginine rich splicing factor 12 Neighboring gene uncharacterized LOC108350948 Neighboring gene RNA guanylyltransferase and 5'-phosphatase Neighboring gene eukaryotic initiation factor 4A-I pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation of a rat bronchiolar epithelial cell cDNA library: isolation of a proline rich protein highly enriched in bronchiolar epithelial cells. Bingle CD. Biochem Biophys Res Commun, 1996 Aug 23. PMID 8780705
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    proline-rich nuclear receptor coactivator 1
    Names
    proline rich 2
    proline-rich protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173322.2 → NP_775444.2  proline-rich nuclear receptor coactivator 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      Q63647
      UniProtKB/TrEMBL
      A6IIL5, R9PXT3
      Related
      ENSRNOP00000010271.6, ENSRNOT00000010271.8
      Conserved Domains (1) summary
      pfam15365
      Location:249 → 267
      PNRC; Proline-rich nuclear receptor coactivator motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      52443400..52489303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039109351.2 → XP_038965279.1  proline-rich nuclear receptor coactivator 1 isoform X1

      Conserved Domains (1) summary
      pfam15365
      Location:108 → 126
      PNRC; Proline-rich nuclear receptor coactivator motif
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q63647.2 GenPept UniProtKB/Swiss-Prot:Q63647

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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