Mtrf1l mitochondrial translation release factor 1 like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtrf1lprovided by RGD
Official Full Name: mitochondrial translation release factor 1 likeprovided by RGD
Primary source: RGD:1598312
See related: EnsemblRapid:ENSRNOG00000018773 AllianceGenome:RGD:1598312
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable translation release factor activity, codon specific. Predicted to be involved in mitochondrial translational termination. Predicted to be active in mitochondrion. Orthologous to human MTRF1L (mitochondrial translation release factor 1 like). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 103.8), Kidney (RPKM 81.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (44614162..44626367, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (42208553..42221020, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (42475791..42485999, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables translation release factor activity	ISO Inferred from Sequence Orthology more info
enables translation release factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables translation release factor activity, codon specific	IEA Inferred from Electronic Annotation more info
enables translation release factor activity, codon specific	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in mitochondrial translational termination	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial translational termination	IEA Inferred from Electronic Annotation more info
involved_in mitochondrial translational termination	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial translational termination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: peptide chain release factor 1-like, mitochondrial

Names: mitochondrial translational release factor 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025723.3 → NP_001020894.1 peptide chain release factor 1-like, mitochondrial precursor

See identical proteins and their annotated locations for NP_001020894.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q4V7E5

UniProtKB/TrEMBL

A0A8L2QF03, A6KIP0

Related

ENSRNOP00000025398.6, ENSRNOT00000025398.9

Conserved Domains (3) summary

COG1186
Location:123 → 355

PrfB; Protein chain release factor B [Translation, ribosomal structure and biogenesis]

pfam00472
Location:224 → 329

RF-1; RF-1 domain

pfam03462
Location:57 → 214

PCRF; PCRF domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

44614162..44626367 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081235.2 → XP_038937163.1 peptide chain release factor 1-like, mitochondrial isoform X1

Conserved Domains (1) summary

cl40670
Location:90 → 279

PCRF; PCRF domain
XM_063266098.1 → XP_063122168.1 peptide chain release factor 1-like, mitochondrial isoform X3
XM_063266088.1 → XP_063122158.1 peptide chain release factor 1-like, mitochondrial isoform X2