Nmbr neuromedin B receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Nmbrprovided by RGD
Full Name: neuromedin B receptorprovided by RGD
Primary source: RGD:3181
See related: EnsemblRapid:ENSRNOG00000012103 AllianceGenome:RGD:3181
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: NMB-R
Summary: Enables neuropeptide receptor activity. Predicted to be involved in several processes, including antiviral innate immune response; positive regulation of osteoclast proliferation; and regulation of cytokine production. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Orthologous to human NMBR (neuromedin B receptor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 15.9), Kidney (RPKM 5.6) and 2 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 1p13

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (10942476..10966174)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (9115033..9146081)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (8933744..8945850)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

peptidergic pathways comprise the core of a sigh control circuit that integrates physiological and perhaps emotional input to transform normal breaths into sighs
Title: The peptidergic control circuit for sighing.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

d1arb44 (e-PCR)
- UniSTS:121445

BF389161 (e-PCR)
- UniSTS:245392

RH94761 (e-PCR)
- UniSTS:120008

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bombesin receptor activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in antiviral innate immune response	IEA Inferred from Electronic Annotation more info
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in antiviral innate immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in bombesin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interferon-alpha production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of osteoclast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of respiratory gaseous exchange	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of respiratory gaseous exchange	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of respiratory gaseous exchange	ISS Inferred from Sequence or Structural Similarity more info
involved_in sneeze reflex	IEA Inferred from Electronic Annotation more info
involved_in sneeze reflex	ISO Inferred from Sequence Orthology more info
involved_in sneeze reflex	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: neuromedin-B receptor

Names: neuromedin-B-preferring bombesin receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012799.2 → NP_036931.1 neuromedin-B receptor

See identical proteins and their annotated locations for NP_036931.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P24053

UniProtKB/TrEMBL

A6JP76

Related

ENSRNOP00000016215.7, ENSRNOT00000016215.8

Conserved Domains (2) summary

cd14964
Location:45 → 71

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:44 → 335

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

10942476..10966174

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101531.2 → XP_038957459.1 neuromedin-B receptor isoform X1

UniProtKB/Swiss-Prot

P24053

UniProtKB/TrEMBL

A6JP76

Conserved Domains (2) summary

cd14964
Location:45 → 71

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:44 → 335

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
XM_063281563.1 → XP_063137633.1 neuromedin-B receptor isoform X1

UniProtKB/Swiss-Prot

P24053

UniProtKB/TrEMBL

A6JP76