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    Ide insulin degrading enzyme [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25700, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ideprovided by RGD
    Official Full Name
    insulin degrading enzymeprovided by RGD
    Primary source
    RGD:2861
    See related
    EnsemblRapid:ENSRNOG00000016833 AllianceGenome:RGD:2861
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    INSDEGM
    Summary
    Enables several functions, including ATP binding activity; ATP hydrolysis activity; and amyloid-beta binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; amyloid-beta metabolic process; and negative regulation of proteolysis. Located in cell surface; extracellular space; and peroxisomal matrix. Part of cytosolic proteasome complex. Used to study Alzheimer's disease and type 2 diabetes mellitus. Biomarker of Alzheimer's disease and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human IDE (insulin degrading enzyme). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 193.2), Muscle (RPKM 191.3) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ide in Genome Data Viewer
    Location:
    1q53
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (244415495..244516925, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (235002984..235102448, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (255914465..256014168, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102549247 Neighboring gene kinesin family member 11 Neighboring gene uncharacterized LOC134483989 Neighboring gene uncharacterized LOC134483990

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables ATP binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables amyloid-beta binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables beta-endorphin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables insulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables insulin binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables insulin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables metalloendopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables peptidase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables peptide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide hormone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in amyloid-beta clearance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in amyloid-beta clearance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amyloid-beta clearance ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amyloid-beta clearance by cellular catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in amyloid-beta clearance by cellular catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amyloid-beta clearance by cellular catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amyloid-beta metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in amyloid-beta metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amyloid-beta metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in amyloid-beta metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in bradykinin catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bradykinin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in bradykinin catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hormone catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hormone catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hormone catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hormone catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in insulin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in insulin metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in insulin receptor recycling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptide catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptide catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptide catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peptide catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis involved in protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis involved in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteolysis involved in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of aerobic respiration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of aerobic respiration ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to oxidative stress ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin recycling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin recycling ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in basolateral plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    part_of cytosolic proteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endosome lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    NOT located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in peroxisomal matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in peroxisomal matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    insulin-degrading enzyme
    Names
    insulin protease
    insulinase
    insulysin
    NP_037291.1
    XP_006231375.1
    XP_038958052.1
    XP_038958055.1
    XP_063138239.1
    XP_063138241.1
    XP_063138244.1
    XP_063138247.1
    XP_063138251.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013159.2NP_037291.1  insulin-degrading enzyme

      See identical proteins and their annotated locations for NP_037291.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P35559
      UniProtKB/TrEMBL
      A0A0G2K7Q7, A6I165
      Related
      ENSRNOP00000074304.3, ENSRNOT00000085303.3
      Conserved Domains (1) summary
      COG1025
      Location:54958
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      244415495..244516925 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231313.5XP_006231375.1  insulin-degrading enzyme isoform X3

      UniProtKB/TrEMBL
      A0A0G2K7Q7, A0A8I6A860
      Related
      ENSRNOP00000088595.1, ENSRNOT00000119683.2
      Conserved Domains (4) summary
      COG1025
      Location:54958
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
      pfam00675
      Location:74212
      Peptidase_M16; Insulinase (Peptidase family M16)
      pfam05193
      Location:238416
      Peptidase_M16_C; Peptidase M16 inactive domain
      pfam16187
      Location:422703
      Peptidase_M16_M; Middle or third domain of peptidase_M16
    2. XM_063282171.1XP_063138241.1  insulin-degrading enzyme isoform X2

      UniProtKB/TrEMBL
      A0A0G2K7Q7
    3. XM_063282169.1XP_063138239.1  insulin-degrading enzyme isoform X1

      UniProtKB/TrEMBL
      A0A0G2K7Q7
    4. XM_063282181.1XP_063138251.1  insulin-degrading enzyme isoform X8

      UniProtKB/TrEMBL
      A0A0G2K7Q7
    5. XM_039102127.2XP_038958055.1  insulin-degrading enzyme isoform X7

      UniProtKB/TrEMBL
      A0A0G2K7Q7, A0A8I6A841
      Related
      ENSRNOP00000087605.1, ENSRNOT00000098836.2
      Conserved Domains (1) summary
      COG1025
      Location:23927
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    6. XM_063282177.1XP_063138247.1  insulin-degrading enzyme isoform X5

      UniProtKB/TrEMBL
      A0A0G2K7Q7
    7. XM_039102124.2XP_038958052.1  insulin-degrading enzyme isoform X6

      UniProtKB/TrEMBL
      A0A0G2K7Q7, A0A8I6A841
      Related
      ENSRNOP00000089992.1, ENSRNOT00000110995.2
      Conserved Domains (1) summary
      COG1025
      Location:23927
      Ptr; Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]
    8. XM_063282174.1XP_063138244.1  insulin-degrading enzyme isoform X4

      UniProtKB/TrEMBL
      A0A0G2K7Q7

    RNA

    1. XR_010063628.1 RNA Sequence