Strn striatin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Strnprovided by RGD
Official Full Name: striatinprovided by RGD
Primary source: RGD:3782
See related: EnsemblRapid:ENSRNOG00000004806 AllianceGenome:RGD:3782
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calmodulin binding activity and protein domain specific binding activity. Involved in dendrite development; locomotory behavior; and regulation of modification of postsynaptic structure. Located in dendritic spine; neuronal cell body; and postsynaptic membrane. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human STRN (striatin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 150.0), Thymus (RPKM 95.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q12

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (22087419..22174284)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (16335265..16422159)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (1232729..1319603, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study demonstrating that aldosterone rapidly enhances renal levels of striatin and caveolin-1 (cav-1). Aldosterone increases striatin levels via an mineralocorticoid receptor (MR)-independent pathway, whereas cav-1 is partially regulated through MR.
Title: Aldosterone Rapidly Enhances Levels of the Striatin and Caveolin-1 Proteins in Rat Kidney: The Role of the Mineralocorticoid Receptor.
Suggest a novel role for striatin in regulating cardiomyocyte spontaneous contraction rate and the dynamics of the STRN/caveolin-3/calmodulin complex.
Title: Cardiac striatin interacts with caveolin-3 and calmodulin in a calcium sensitive manner and regulates cardiomyocyte spontaneous contraction rate.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	IEA Inferred from Electronic Annotation more info
enables armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein binding	NAS Non-traceable Author Statement more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	IEA Inferred from Electronic Annotation more info
enables nuclear estrogen receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in dendrite development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of modification of postsynaptic structure	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic structure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of FAR/SIN/STRIPAK complex	IEA Inferred from Electronic Annotation more info
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
located_in bicellular tight junction	IEA Inferred from Electronic Annotation more info
located_in bicellular tight junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: striatin

Names: striatin, calmodulin binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019148.3 → NP_062021.2 striatin

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P70483

UniProtKB/TrEMBL

A6H9V7, G3V6L8

Related

ENSRNOP00000006527.4, ENSRNOT00000006527.7

Conserved Domains (3) summary

cd00200
Location:455 → 779

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:468 → 514

7WD40; WD40 repeat [structural motif]

pfam08232
Location:49 → 173

Striatin; Striatin family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

22087419..22174284

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006239622.5 → XP_006239684.1 striatin isoform X1

UniProtKB/Swiss-Prot

P70483

UniProtKB/TrEMBL

A0A8I6AG38

Related

ENSRNOP00000093598.1, ENSRNOT00000118929.2

Conserved Domains (4) summary

COG2319
Location:478 → 807

WD40; WD40 repeat [General function prediction only]

cd00200
Location:484 → 808

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:48 → 173

Striatin; Striatin family

sd00039
Location:497 → 543

7WD40; WD40 repeat [structural motif]
XM_039111825.2 → XP_038967753.1 striatin isoform X2

Conserved Domains (2) summary

cd00200
Location:267 → 591

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:280 → 326

7WD40; WD40 repeat [structural motif]