Grik5 glutamate ionotropic receptor kainate type subunit 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grik5provided by RGD
Official Full Name: glutamate ionotropic receptor kainate type subunit 5provided by RGD
Primary source: RGD:2735
See related: EnsemblRapid:ENSRNOG00000020310 AllianceGenome:RGD:2735
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: GluK5; iGlu5
Summary: Enables identical protein binding activity; kainate selective glutamate receptor activity; and protein domain specific binding activity. Contributes to glutamate-gated receptor activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of neuron apoptotic process; and protein retention in ER lumen. Located in several cellular components, including dendrite; perikaryon; and terminal bouton. Part of ionotropic glutamate receptor complex. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Used to study visual epilepsy. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human GRIK5 (glutamate ionotropic receptor kainate type subunit 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 64.7), Kidney (RPKM 26.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (89733736..89795769, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (80605878..80667896, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (81885516..81946731, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that ligand binding to only the GluK5 subunit is both necessary and sufficient to allow trafficking of recombinant GluK2/K5 heteromers to the cell membrane, but that occupancy of the GluK2 site alone is not.
Title: Agonist binding to the GluK5 subunit is sufficient for functional surface expression of heteromeric GluK2/GluK5 kainate receptors.
GluK2 and GluK5 assemble with 2:2 stoichiometry.
Title: Assembly stoichiometry of the GluK2/GluK5 kainate receptor complex.
CaMKII-dependent phosphorylation of GluK5 is responsible for synaptic depression by untrapping of KARs from the PSD and increased diffusion away from synaptic sites.
Title: CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors.
Heteromeric GluK2/K5 receptors expressed in human HEK-293T cells show markedly higher glutamate sensitivity than GluK2 homomers and do not desensitize at low glutamate concentrations.
Title: Distinct functional roles of subunits within the heteromeric kainate receptor.
kainic acid-preferring glutamate receptors are responsive to changes in plasma glucose concentrations and may participate in the activation of the paraventricular neurones during hypoglycaemic stress
Title: Provocation of kainic acid receptor mRNA changes in the rat paraventricular nucleus by insulin-induced hypoglycaemia.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF404569 (e-PCR)
- UniSTS:247145

RH139022 (e-PCR)
- UniSTS:221108

D1Wox65 (e-PCR)
- UniSTS:239570

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables SH3 domain binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to glutamate-gated receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to glutamate-gated receptor activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kainate selective glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables kainate selective glutamate receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables kainate selective glutamate receptor activity	IEA Inferred from Electronic Annotation more info
enables kainate selective glutamate receptor activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to glucose stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in excitatory postsynaptic potential	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within excitatory postsynaptic potential	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein retention in ER lumen	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in receptor clustering	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of presynaptic membrane potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of synaptic vesicle fusion to presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in hippocampal mossy fiber to CA3 synapse	IEA Inferred from Electronic Annotation more info
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
part_of ionotropic glutamate receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of kainate selective glutamate receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of kainate selective glutamate receptor complex	IEA Inferred from Electronic Annotation more info
part_of kainate selective glutamate receptor complex	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in postsynaptic membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in presynaptic membrane	ISO Inferred from Sequence Orthology more info
located_in terminal bouton	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate receptor ionotropic, kainate 5

Names: KA2; glutamate receptor KA-2; glutamate receptor KA2; glutamate receptor, ionotropic, kainate 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031508.2 → NP_113696.1 glutamate receptor ionotropic, kainate 5 precursor

See identical proteins and their annotated locations for NP_113696.1

Status: VALIDATED

Source sequence(s)

BC101853, Z11581

UniProtKB/Swiss-Prot

Q62643, Q63273

UniProtKB/TrEMBL

A0A8I6ABK8, A6J936

Conserved Domains (2) summary

cd06394
Location:23 → 401

PBP1_iGluR_Kainate_KA1_2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor

cl21456
Location:414 → 784

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

89733736..89795769 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039095322.2 → XP_038951250.1 glutamate receptor ionotropic, kainate 5 isoform X3

UniProtKB/TrEMBL

A0A8I6ABK8

Conserved Domains (2) summary

cl10011
Location:1 → 320

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl21456
Location:333 → 704

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_006228382.5 → XP_006228444.1 glutamate receptor ionotropic, kainate 5 isoform X1

See identical proteins and their annotated locations for XP_006228444.1

UniProtKB/TrEMBL

A0A8I6ABK8, A0A8L2QF05

Related

ENSRNOP00000027578.4, ENSRNOT00000027578.8

Conserved Domains (2) summary

cd06394
Location:23 → 401

PBP1_iGluR_Kainate_KA1_2; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor

cl21456
Location:414 → 785

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_008758889.4 → XP_008757111.1 glutamate receptor ionotropic, kainate 5 isoform X2

UniProtKB/TrEMBL

A0A8I6ABK8

Related

ENSRNOP00000091191.1, ENSRNOT00000107115.2

Conserved Domains (4) summary

cd06394
Location:25 → 381

PBP1_iGluR_Kainate_KA1_2; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the KA1 and KA2 subunits of Kainate receptor

pfam00060
Location:528 → 798

Lig_chan; Ligand-gated ion channel

pfam01094
Location:42 → 361

ANF_receptor; Receptor family ligand binding region

cl21456
Location:396 → 767

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
XM_039095358.2 → XP_038951286.1 glutamate receptor ionotropic, kainate 5 isoform X4

Conserved Domains (2) summary

cl10011
Location:5 → 179

Periplasmic_Binding_Protein_type1; Type 1 periplasmic binding fold superfamily

cl21456
Location:192 → 563

Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily