U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    hgo-1 Homogentisate 1,2-dioxygenase [ Caenorhabditis elegans ]

    Gene ID: 172726, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    hgo-1
    Official Full Name
    Homogentisate 1,2-dioxygenase
    Primary source
    WormBase:WBGene00001843
    Locus tag
    CELE_W06D4.1
    See related
    AllianceGenome:WB:WBGene00001843
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable homogentisate 1,2-dioxygenase activity. Predicted to be involved in L-phenylalanine catabolic process. Located in striated muscle dense body. Is expressed in body wall musculature; hypodermis; intestine; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in alkaptonuria. Orthologous to human HGD (homogentisate 1,2-dioxygenase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See hgo-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    9
    Sequence:
    Chromosome: I; NC_003279.8 (9049460..9055457, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene BAAT/Acyl-CoA thioester hydrolase C-terminal domain-containing protein;BAAT/acyl-CoA thioester hydrolase protein Neighboring gene Uncharacterized protein Neighboring gene tRNA-Asn Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Integral membrane protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The Caenorhabditis elegans K10C2.4 gene encodes a member of the fumarylacetoacetate hydrolase family: a Caenorhabditis elegans model of type I tyrosinemia. Fisher AL, et al. J Biol Chem, 2008 Apr 4. PMID 18227072, Free PMC Article
    2. Transcriptional targets of DAF-16 insulin signaling pathway protect C. elegans from extreme hypertonic stress. Lamitina ST, et al. Am J Physiol Cell Physiol, 2005 Feb. PMID 15496475
    3. A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans. Manage KI, et al. Elife, 2020 Apr 27. PMID 32338603, Free PMC Article
    4. skn-1-Dependent and -independent regulation of aip-1 expression following metabolic stress in Caenorhabditis elegans. Ferguson AA, et al. Mol Cell Biol, 2010 Jun. PMID 20351174, Free PMC Article
    5. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables homogentisate 1,2-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables homogentisate 1,2-dioxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tyrosine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in striated muscle dense body HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Homogentisate 1,2-dioxygenase
    NP_492433.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      9049460..9055457 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060032.7 → NP_492433.1  Homogentisate 1,2-dioxygenase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492433.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O62087, Q9NJP3, Q9Y041
      Conserved Domains (1) summary
      TIGR01015
      Location:6 → 433
      hmgA; homogentisate 1,2-dioxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y041.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous