unc-68 Ryanodine receptor [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: unc-68
Official Full Name: Ryanodine receptor
Primary source: WormBase:WBGene00006801
Locus tag: CELE_K11C4.5
See related: AllianceGenome:WB:WBGene00006801
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium ion binding activity and ryanodine-sensitive calcium-release channel activity. Involved in locomotion; positive regulation of programmed cell death; and protein localization to organelle. Located in I band and sarcoplasmic reticulum. Is expressed in body wall musculature; intestine; muscle cell; and neurons. Used to study congenital myopathy 1A and malignant hyperthermia. Human ortholog(s) of this gene implicated in several diseases, including catecholaminergic polymorphic ventricular tachycardia 1; congestive heart failure (multiple); hepatocellular carcinoma; intracranial vasospasm; and muscle tissue disease (multiple). Orthologous to human RYR1 (ryanodine receptor 1); RYR2 (ryanodine receptor 2); and RYR3 (ryanodine receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-68 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 51

Sequence:: Chromosome: V; NC_003283.11 (6901681..6929038, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions.
Title: Tissue-specific isoforms of the single C. elegans Ryanodine receptor gene unc-68 control specific functions.
Loss-of-function mutations of the ryanodine gene unc-68 (uncoordinated 68) essentially abolished large-amplitude miniature postsynaptic currents
Title: Presynaptic ryanodine receptors are required for normal quantal size at the Caenorhabditis elegans neuromuscular junction.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K11C4.5 (e-PCR)
- UniSTS:311552

Y57E12_245.a (e-PCR)
- UniSTS:323159

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ryanodine-sensitive calcium-release channel activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in ligand-gated ion channel signaling pathway	HEP more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of programmed cell death	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to organelle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in I band	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ryanodine receptor

NP_001343688.1

Confirmed by transcript evidence

NP_001343689.1

Confirmed by transcript evidence

NP_001343695.1

Confirmed by transcript evidence

NP_001343696.1

Confirmed by transcript evidence

NP_001343808.1

Partially confirmed by transcript evidence

NP_001343809.1

Partially confirmed by transcript evidence

NP_001343810.1

Partially confirmed by transcript evidence

NP_001343811.1

Partially confirmed by transcript evidence

NP_001343812.1

Confirmed by transcript evidence

NP_001343813.1

Confirmed by transcript evidence

NP_001343814.1

Confirmed by transcript evidence

NP_001343815.1

Confirmed by transcript evidence

NP_001343816.1

Partially confirmed by transcript evidence

NP_001343817.1

Partially confirmed by transcript evidence

NP_001343818.1

Partially confirmed by transcript evidence

NP_001343819.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6901681..6929038 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001356679.3 → NP_001343688.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

G4SNF8, P91905, Q94279

Conserved Domains (11) summary

cd00051
Location:4320 → 4374

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:652 → 799

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1078 → 1210

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1542 → 1692

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4968 → 5110

Ion_trans; Ion transport protein

pfam01365
Location:449 → 646

RYDR_ITPR; RIH domain

pfam02026
Location:853 → 941

RyR; RyR domain

pfam02815
Location:220 → 399

MIR; MIR domain

pfam06459
Location:4661 → 4841

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:4124 → 4237

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:13 → 209

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356673.4 → NP_001343696.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

I2HAA7, P91905

Conserved Domains (11) summary

cd00051
Location:4190 → 4244

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:652 → 799

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1078 → 1210

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1542 → 1692

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4838 → 4980

Ion_trans; Ion transport protein

pfam01365
Location:449 → 646

RYDR_ITPR; RIH domain

pfam02026
Location:853 → 941

RyR; RyR domain

pfam02815
Location:220 → 399

MIR; MIR domain

pfam06459
Location:4531 → 4711

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3994 → 4107

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:13 → 209

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356677.4 → NP_001343695.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

I2HAA6, P91905

Conserved Domains (11) summary

cd00051
Location:4306 → 4360

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:652 → 799

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1078 → 1210

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1542 → 1692

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4954 → 5096

Ion_trans; Ion transport protein

pfam01365
Location:449 → 646

RYDR_ITPR; RIH domain

pfam02026
Location:853 → 941

RyR; RyR domain

pfam02815
Location:220 → 399

MIR; MIR domain

pfam06459
Location:4647 → 4827

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:4110 → 4223

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:13 → 209

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356678.4 → NP_001343810.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3F1, P91905

Conserved Domains (11) summary

cd00051
Location:4307 → 4361

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:652 → 799

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1078 → 1210

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1542 → 1692

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4955 → 5097

Ion_trans; Ion transport protein

pfam01365
Location:449 → 646

RYDR_ITPR; RIH domain

pfam02026
Location:853 → 941

RyR; RyR domain

pfam02815
Location:220 → 399

MIR; MIR domain

pfam06459
Location:4648 → 4828

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:4111 → 4224

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:13 → 209

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356680.4 → NP_001343808.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3E8, P91905

Conserved Domains (11) summary

cd00051
Location:4321 → 4375

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:652 → 799

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1078 → 1210

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1542 → 1692

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4969 → 5111

Ion_trans; Ion transport protein

pfam01365
Location:449 → 646

RYDR_ITPR; RIH domain

pfam02026
Location:853 → 941

RyR; RyR domain

pfam02815
Location:220 → 399

MIR; MIR domain

pfam06459
Location:4662 → 4842

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:4125 → 4238

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:13 → 209

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356674.3 → NP_001343811.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C390, P91905

Conserved Domains (11) summary

cd00051
Location:4191 → 4245

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:652 → 799

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1078 → 1210

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1542 → 1692

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4839 → 4981

Ion_trans; Ion transport protein

pfam01365
Location:449 → 646

RYDR_ITPR; RIH domain

pfam02026
Location:853 → 941

RyR; RyR domain

pfam02815
Location:220 → 399

MIR; MIR domain

pfam06459
Location:4532 → 4712

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3995 → 4108

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:13 → 209

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356675.3 → NP_001343689.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

B7WN66, G4SNF7, P91905

Conserved Domains (11) summary

cd00051
Location:4204 → 4258

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:652 → 799

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1078 → 1210

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1542 → 1692

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4852 → 4994

Ion_trans; Ion transport protein

pfam01365
Location:449 → 646

RYDR_ITPR; RIH domain

pfam02026
Location:853 → 941

RyR; RyR domain

pfam02815
Location:220 → 399

MIR; MIR domain

pfam06459
Location:4545 → 4725

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:4008 → 4121

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:13 → 209

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356676.3 → NP_001343809.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C354, P91905

Conserved Domains (11) summary

cd00051
Location:4205 → 4259

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:652 → 799

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1078 → 1210

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1542 → 1692

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4853 → 4995

Ion_trans; Ion transport protein

pfam01365
Location:449 → 646

RYDR_ITPR; RIH domain

pfam02026
Location:853 → 941

RyR; RyR domain

pfam02815
Location:220 → 399

MIR; MIR domain

pfam06459
Location:4546 → 4726

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:4009 → 4122

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:13 → 209

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356681.3 → NP_001343815.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C325, P91905

Conserved Domains (11) summary

cd00051
Location:4188 → 4242

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:650 → 797

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1076 → 1208

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1540 → 1690

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4836 → 4978

Ion_trans; Ion transport protein

pfam01365
Location:447 → 644

RYDR_ITPR; RIH domain

pfam02026
Location:851 → 939

RyR; RyR domain

pfam02815
Location:218 → 397

MIR; MIR domain

pfam06459
Location:4529 → 4709

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3992 → 4105

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:19 → 207

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356682.3 → NP_001343819.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C370, P91905

Conserved Domains (11) summary

cd00051
Location:4189 → 4243

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:650 → 797

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1076 → 1208

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1540 → 1690

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4837 → 4979

Ion_trans; Ion transport protein

pfam01365
Location:447 → 644

RYDR_ITPR; RIH domain

pfam02026
Location:851 → 939

RyR; RyR domain

pfam02815
Location:218 → 397

MIR; MIR domain

pfam06459
Location:4530 → 4710

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3993 → 4106

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:19 → 207

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356683.3 → NP_001343813.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3I4, P91905

Conserved Domains (11) summary

cd00051
Location:4202 → 4256

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:650 → 797

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1076 → 1208

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1540 → 1690

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4850 → 4992

Ion_trans; Ion transport protein

pfam01365
Location:447 → 644

RYDR_ITPR; RIH domain

pfam02026
Location:851 → 939

RyR; RyR domain

pfam02815
Location:218 → 397

MIR; MIR domain

pfam06459
Location:4543 → 4723

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:4006 → 4119

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:19 → 207

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356684.3 → NP_001343817.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C388, P91905

Conserved Domains (11) summary

cd00051
Location:4203 → 4257

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:650 → 797

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1076 → 1208

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1540 → 1690

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4851 → 4993

Ion_trans; Ion transport protein

pfam01365
Location:447 → 644

RYDR_ITPR; RIH domain

pfam02026
Location:851 → 939

RyR; RyR domain

pfam02815
Location:218 → 397

MIR; MIR domain

pfam06459
Location:4544 → 4724

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:4007 → 4120

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:19 → 207

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356685.3 → NP_001343814.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C2X2, P91905

Conserved Domains (11) summary

cd00051
Location:4304 → 4358

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:650 → 797

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1076 → 1208

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1540 → 1690

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4952 → 5094

Ion_trans; Ion transport protein

pfam01365
Location:447 → 644

RYDR_ITPR; RIH domain

pfam02026
Location:851 → 939

RyR; RyR domain

pfam02815
Location:218 → 397

MIR; MIR domain

pfam06459
Location:4645 → 4825

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:4108 → 4221

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:19 → 207

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356686.3 → NP_001343818.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3G1, P91905

Conserved Domains (11) summary

cd00051
Location:4305 → 4359

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:650 → 797

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1076 → 1208

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1540 → 1690

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4953 → 5095

Ion_trans; Ion transport protein

pfam01365
Location:447 → 644

RYDR_ITPR; RIH domain

pfam02026
Location:851 → 939

RyR; RyR domain

pfam02815
Location:218 → 397

MIR; MIR domain

pfam06459
Location:4646 → 4826

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:4109 → 4222

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:19 → 207

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356687.3 → NP_001343812.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C3P6, P91905

Conserved Domains (11) summary

cd00051
Location:4318 → 4372

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:650 → 797

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1076 → 1208

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1540 → 1690

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4966 → 5108

Ion_trans; Ion transport protein

pfam01365
Location:447 → 644

RYDR_ITPR; RIH domain

pfam02026
Location:851 → 939

RyR; RyR domain

pfam02815
Location:218 → 397

MIR; MIR domain

pfam06459
Location:4659 → 4839

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:4122 → 4235

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:19 → 207

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
NM_001356688.3 → NP_001343816.1 Ryanodine receptor [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A2C9C384, P91905

Conserved Domains (11) summary

cd00051
Location:4319 → 4373

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

cd12877
Location:650 → 797

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1076 → 1208

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1540 → 1690

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4967 → 5109

Ion_trans; Ion transport protein

pfam01365
Location:447 → 644

RYDR_ITPR; RIH domain

pfam02026
Location:851 → 939

RyR; RyR domain

pfam02815
Location:218 → 397

MIR; MIR domain

pfam06459
Location:4660 → 4840

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:4123 → 4236

RIH_assoc; RyR and IP3R Homology associated

cl19745
Location:19 → 207

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor