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    unc-44 AO66 ankyrin;Ankyrin-2;Trans-sialidase;UNC-44;ZU5 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177366, updated on 9-Dec-2024

    Summary

    Official Symbol
    unc-44
    Official Full Name
    AO66 ankyrin;Ankyrin-2;Trans-sialidase;UNC-44;ZU5 domain-containing protein
    Primary source
    WormBase:WBGene00006780
    Locus tag
    CELE_B0350.2
    See related
    AllianceGenome:WB:WBGene00006780
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables cell adhesion molecule binding activity. Involved in several processes, including axon guidance; establishment or maintenance of cytoskeleton polarity; and netrin-activated signaling pathway. Located in lateral plasma membrane. Is expressed in several structures, including hermaphrodite gonad; hypodermis; intestine; muscle cell; and nervous system. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); ankyrin-B-related cardiac arrhythmia; autosomal recessive intellectual developmental disorder 37; bipolar disorder; and heart conduction disease (multiple). Orthologous to several human genes including ANK2 (ankyrin 2) and ANK3 (ankyrin 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See unc-44 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    20
    Sequence:
    Chromosome: IV; NC_003282.8 (5975557..6004857)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    AO66 ankyrin;Ankyrin-2;Trans-sialidase;UNC-44;ZU5 domain-containing protein
    NP_001021266.2
    • Partially confirmed by transcript evidence
    NP_001021267.1
    • Confirmed by transcript evidence
    NP_001367343.1
    • Confirmed by transcript evidence
    NP_001367344.1
    • Confirmed by transcript evidence
    NP_001367345.1
    • Confirmed by transcript evidence
    NP_001368407.1
    • Confirmed by transcript evidence
    NP_001368408.1
    • Confirmed by transcript evidence
    NP_001368409.1
    • Confirmed by transcript evidence
    NP_500901.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      5975557..6004857
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001380250.2NP_001367343.1  Ankyrin-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECZ1
      Conserved Domains (8) summary
      smart00218
      Location:10001104
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02876
      Location:242648
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:37387
      PHA03095; ankyrin-like protein; Provisional
      cd08317
      Location:14971574
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:424455
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:756807
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13311466
      UPA_2; UPA domain
      cl39094
      Location:555780
      Ank_2; Ankyrin repeats (3 copies)
    2. NM_001380251.2NP_001367344.1  AO66 ankyrin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MQG0
      Conserved Domains (8) summary
      smart00218
      Location:10001104
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02876
      Location:242648
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:37387
      PHA03095; ankyrin-like protein; Provisional
      cd08317
      Location:14971574
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:424455
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:756807
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13311466
      UPA_2; UPA domain
      cl39094
      Location:555780
      Ank_2; Ankyrin repeats (3 copies)
    3. NM_001380252.2NP_001368407.1  Ankyrin-2 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7JP86
      Conserved Domains (8) summary
      smart00218
      Location:10081110
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02876
      Location:242648
      PHA02876; ankyrin repeat protein; Provisional
      PHA03095
      Location:37387
      PHA03095; ankyrin-like protein; Provisional
      cd08317
      Location:15031580
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:424455
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:756807
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13371472
      UPA_2; UPA domain
      cl39094
      Location:555780
      Ank_2; Ankyrin repeats (3 copies)
    4. NM_001380249.1NP_001367345.1  AO66 ankyrin [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17343, Q17490
      Conserved Domains (9) summary
      smart00218
      Location:10081110
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      PHA02876
      Location:242648
      PHA02876; ankyrin repeat protein; Provisional
      PTZ00449
      Location:17702112
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      PHA03095
      Location:37387
      PHA03095; ankyrin-like protein; Provisional
      cd08317
      Location:15031580
      Death_ank; Death domain associated with Ankyrins
      sd00045
      Location:424455
      ANK; ANK repeat [structural motif]
      pfam13637
      Location:756807
      Ank_4; Ankyrin repeats (many copies)
      pfam17809
      Location:13371472
      UPA_2; UPA domain
      cl39094
      Location:555780
      Ank_2; Ankyrin repeats (3 copies)
    5. NM_001380253.1NP_001368408.1  UNC-44 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17341, V6CLS7
      Conserved Domains (3) summary
      smart00218
      Location:167271
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08317
      Location:664741
      Death_ank; Death domain associated with Ankyrins
      pfam17809
      Location:498633
      UPA_2; UPA domain
    6. NM_001380254.1NP_001368409.1  UNC-44 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17341, V6CLR6
      Conserved Domains (3) summary
      smart00218
      Location:175277
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08317
      Location:670747
      Death_ank; Death domain associated with Ankyrins
      pfam17809
      Location:504639
      UPA_2; UPA domain
    7. NM_068500.5NP_500901.2  ZU5 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500901.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17341, Q5TYL6
      Conserved Domains (2) summary
      smart00218
      Location:96200
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08317
      Location:593670
      Death_ank; Death domain associated with Ankyrins
    8. NM_001026096.4NP_001021267.1  ZU5 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001021267.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17342, Q5TYL5
      Conserved Domains (2) summary
      smart00218
      Location:190
      ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
      cd08317
      Location:483560
      Death_ank; Death domain associated with Ankyrins
    9. NM_001026095.6NP_001021266.2  Trans-sialidase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17489