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    upk1a uroplakin 1a [ Danio rerio (zebrafish) ]

    Gene ID: 678515, updated on 4-Jan-2025

    Summary

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    Official Symbol
    upk1aprovided by ZNC
    Official Full Name
    uroplakin 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060421-2603
    See related
    Ensembl:ENSDARG00000021866 AllianceGenome:ZFIN:ZDB-GENE-060421-2603
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb14a02; fk84c04; wu:fb14a02; wu:fk84c04; zgc:136832
    Summary
    Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human UPK1A (uroplakin 1A). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See upk1a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (44768336..44780744)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (44801612..44814028)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene zmp:0000000951 Neighboring gene family with sequence similarity 83 member A Neighboring gene Rho GTPase activating protein 33 Neighboring gene RNA binding motif protein 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Origin of the tetraspanin uroplakins and their co-evolution with associated proteins: implications for uroplakin structure and function. Garcia-España A, et al. Mol Phylogenet Evol, 2006 Nov. PMID 16814572
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC136832

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uroplakin-1a

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001040242.1 → NP_001035332.1  uroplakin-1a

      See identical proteins and their annotated locations for NP_001035332.1

      Status: PROVISIONAL

      Source sequence(s)
      BC115285
      UniProtKB/TrEMBL
      A0A8M2B4S7, Q1RLU3
      Related
      ENSDARP00000037144.7, ENSDART00000036302.8
      Conserved Domains (2) summary
      cd03156
      Location:103 → 221
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:30 → 246
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      44768336..44780744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158400.5 → XP_005158457.1  uroplakin-1a isoform X1

      See identical proteins and their annotated locations for XP_005158457.1

      UniProtKB/TrEMBL
      A0A8M2B4S7, Q1RLU3
      Conserved Domains (2) summary
      cd03156
      Location:103 → 221
      uroplakin_I_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:30 → 246
      Tetraspannin; Tetraspanin family
    Nucleotide Protein Strain
    Heading Accession and Version

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