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    trim105 tripartite motif containing 105 [ Danio rerio (zebrafish) ]

    Gene ID: 100170828, updated on 4-Jan-2025

    Summary

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    Official Symbol
    trim105provided by ZNC
    Official Full Name
    tripartite motif containing 105provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060810-140
    See related
    Ensembl:ENSDARG00000099885 AllianceGenome:ZFIN:ZDB-GENE-060810-140
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7159455; zgc:193699
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in innate immune response. Predicted to be active in cytoplasm. Orthologous to human TRIM69 (tripartite motif containing 69). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See trim105 in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (15972125..15990332, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (15668156..15684835, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene endoplasmic reticulum-golgi intermediate compartment 1 Neighboring gene fms related receptor tyrosine kinase 4 Neighboring gene neuropeptide Y receptor Y7 Neighboring gene PRELI domain containing 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish. Boudinot P, et al. PLoS One, 2011. PMID 21789205, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    tripartite motif containing 105

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130662.1 → NP_001124134.1  tripartite motif containing 105

      See identical proteins and their annotated locations for NP_001124134.1

      Status: PROVISIONAL

      Source sequence(s)
      BC162527
      UniProtKB/TrEMBL
      B3DGU9
      Related
      ENSDARP00000131990.1, ENSDART00000168075.2
      Conserved Domains (3) summary
      cd00162
      Location:15 → 60
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd12905
      Location:244 → 421
      SPRY_PRY_A33L; zinc-binding protein A33-like
      cl23777
      Location:117 → 203
      PRK01558; V-type ATP synthase subunit E; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      15972125..15990332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021480956.2 → XP_021336631.1  tripartite motif containing 105 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QKG1
      Conserved Domains (2) summary
      cd12905
      Location:212 → 389
      SPRY_PRY_A33L; zinc-binding protein A33-like
      cl17238
      Location:13 → 57
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    2. XM_005157189.5 → XP_005157246.1  tripartite motif containing 105 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B3Z9
      Conserved Domains (3) summary
      cd00162
      Location:15 → 60
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      cd12905
      Location:243 → 420
      SPRY_PRY_A33L; zinc-binding protein A33-like
      cl23777
      Location:116 → 202
      PRK01558; V-type ATP synthase subunit E; Provisional
    Nucleotide Protein
    Heading Accession and Version

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