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    ttc-17 TPR_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179275, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ttc-17
    Official Full Name
    TPR_REGION domain-containing protein
    Primary source
    WormBase:WBGene00020553
    Locus tag
    CELE_T19A5.1
    See related
    AllianceGenome:WB:WBGene00020553
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in actin filament polymerization. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in head neurons; hypodermis; intestine; and vulva. Orthologous to human TTC17 (tetratricopeptide repeat domain 17). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ttc-17 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    16
    Sequence:
    Chromosome: V; NC_003283.11 (8957045..8961935)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Germinal center kinase 1;non-specific serine/threonine protein kinase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-44 Neighboring gene Nuclear Hormone Receptor family Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding. Hannich JT, et al. Nat Metab, 2019 Oct. PMID 32694842
    2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
    3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TPR_REGION domain-containing protein
    NP_505312.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      8957045..8961935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_072911.8 → NP_505312.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505312.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22554
      Conserved Domains (2) summary
      sd00006
      Location:1156 → 1185
      TPR; TPR repeat [structural motif]
      pfam13414
      Location:1195 → 1256
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version

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