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    toca-2 Transducer of Cdc42-dependent actin assembly protein 2 homolog [ Caenorhabditis elegans ]

    Gene ID: 176812, updated on 9-Dec-2024

    Summary

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    Official Symbol
    toca-2
    Official Full Name
    Transducer of Cdc42-dependent actin assembly protein 2 homolog
    Primary source
    WormBase:WBGene00010663
    Locus tag
    CELE_K08E3.3
    See related
    AllianceGenome:WB:WBGene00010663
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in several processes, including negative regulation of protein localization to adherens junction; positive regulation of clathrin-dependent endocytosis; and positive regulation of egg-laying behavior. Located in several cellular components, including cell-cell junction; intracellular vesicle; and plasma membrane. Is expressed in spermatheca and uterus. Orthologous to human FNBP1 (formin binding protein 1); FNBP1L (formin binding protein 1 like); and TRIP10 (thyroid hormone receptor interactor 10). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See toca-2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    15
    Sequence:
    Chromosome: III; NC_003281.10 (13755896..13759445)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene EF-hand domain-containing protein Neighboring gene ncRNA Neighboring gene DreBriN 1/DreBriN-like (where Drebrin is from Developmentally REgulated BRaIN protein) family homolog Neighboring gene UTP--glucose-1-phosphate uridylyltransferase Neighboring gene Rac GTPase-activating protein 1 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease. Holbert S, et al. Proc Natl Acad Sci U S A, 2003 Mar 4. PMID 12604778, Free PMC Article
    2. A TOCA/CDC-42/PAR/WAVE functional module required for retrograde endocytic recycling. Bai Z, et al. Proc Natl Acad Sci U S A, 2015 Mar 24. PMID 25775511, Free PMC Article
    3. Spatial control of active CDC-42 during collective migration of hypodermal cells in Caenorhabditis elegans. Ouellette MH, et al. J Mol Cell Biol, 2016 Aug. PMID 26578656, Free PMC Article
    4. Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis. Giuliani C, et al. PLoS Genet, 2009 Oct. PMID 19798448, Free PMC Article
    5. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TOCA-1 and TOCA-2 are important for the regulation of Clathrin-mediated endocytic processes during oocyte growth, and in the control of epithelial morphogenesis in developing embryos.
      Title: Requirements for F-BAR proteins TOCA-1 and TOCA-2 in actin dynamics and membrane trafficking during Caenorhabditis elegans oocyte growth and embryonic epidermal morphogenesis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic ectodermal digestive tract morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in embryonic ectodermal digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein localization to adherens junction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of clathrin-dependent endocytosis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of clathrin-dependent endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of egg-laying behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of actin cytoskeleton organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in recycling endosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Transducer of Cdc42-dependent actin assembly protein 2 homolog
    NP_499838.2
    • Confirmed by transcript evidence
    NP_499839.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13755896..13759445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_067438.5 → NP_499839.2  Transducer of Cdc42-dependent actin assembly protein 2 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499839.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9XUS7
      Conserved Domains (3) summary
      cd07653
      Location:8 → 267
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:356 → 431
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:551 → 606
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4

    2. NM_067437.6 → NP_499838.2  Transducer of Cdc42-dependent actin assembly protein 2 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499838.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U3B8, Q9XUS7
      Conserved Domains (3) summary
      cd07653
      Location:8 → 267
      F-BAR_CIP4-like; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11619
      Location:356 → 431
      HR1_CIP4-like; Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Cdc42-Interacting Protein 4 and similar proteins
      cd11911
      Location:551 → 608
      SH3_CIP4-like; Src Homology 3 domain of Cdc42-Interacting Protein 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9XUS7.2

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