rgs12b regulator of G protein signaling 12b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rgs12bprovided by ZNC
Official Full Name: regulator of G protein signaling 12bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031006-13
See related: Ensembl:ENSDARG00000036774 AllianceGenome:ZFIN:ZDB-GENE-031006-13
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb958; rgs12; RGS12TS; RGS12TS-I; RGS12TS-L; RGS12TS-S
Summary: Predicted to enable GTPase activator activity. Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Is expressed in retina and ventricular zone. Orthologous to human RGS12 (regulator of G protein signaling 12). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (41201231..41290613, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (40498763..40587829, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables GTPase regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: regulator of G-protein signaling 12b

Names: regulator of G-protein signalling 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_214724.1 → NP_999889.1 regulator of G-protein signaling 12b

See identical proteins and their annotated locations for NP_999889.1

Status: PROVISIONAL

Source sequence(s)

AY427669

UniProtKB/TrEMBL

Q6T9C3, Q6T9C4

Related

ENSDARP00000015580.7, ENSDART00000022546.9

Conserved Domains (9) summary

cd01817
Location:993 → 1065

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08742
Location:741 → 855

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

cd00992
Location:20 → 96

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:239 → 372

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

pfam02188
Location:1195 → 1216

GoLoco; GoLoco motif

pfam16611
Location:1141 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1307 → 1367

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:861 → 954

RGS12_us1; Unstructured region of RGS12

cl00155
Location:1065 → 1132

UBQ; Ubiquitin-like proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

41201231..41290613 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160017.5 → XP_005160074.1 regulator of G-protein signaling 12b isoform X4

See identical proteins and their annotated locations for XP_005160074.1

UniProtKB/TrEMBL

Q6T9C3, Q6T9C4

Conserved Domains (9) summary

cd01817
Location:993 → 1065

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08742
Location:741 → 855

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

cd00992
Location:20 → 96

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:239 → 372

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

pfam02188
Location:1195 → 1216

GoLoco; GoLoco motif

pfam16611
Location:1141 → 1180

RGS12_us2; Unstructured region between RBD and GoLoco

pfam16612
Location:1307 → 1367

RGS12_usC; C-terminal unstructured region of RGS12

pfam16613
Location:861 → 954

RGS12_us1; Unstructured region of RGS12

cl00155
Location:1065 → 1132

UBQ; Ubiquitin-like proteins
XM_009292984.3 → XP_009291259.1 regulator of G-protein signaling 12b isoform X2

See identical proteins and their annotated locations for XP_009291259.1

UniProtKB/TrEMBL

Q6T9C1, Q6T9C5

Related

ENSDARP00000106896.2, ENSDART00000125988.4

Conserved Domains (6) summary

cd01817
Location:993 → 1065

RGS12_RBD; Ubiquitin domain of RGS12 and RGS14

cd08742
Location:741 → 855

RGS_RGS12; Regulator of G protein signaling (RGS) domain found in the RGS12 protein

cd00992
Location:20 → 96

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

cd13162
Location:239 → 372

PTB_RGS12; Regulator of G-protein signaling 12 Phosphotyrosine-binding (PTB) PH-like fold

pfam16613
Location:861 → 954

RGS12_us1; Unstructured region of RGS12

cl00155
Location:1065 → 1132

UBQ; Ubiquitin-like proteins
XM_068213183.1 → XP_068069284.1 regulator of G-protein signaling 12b isoform X1

UniProtKB/TrEMBL

Q6SPF1, Q6T9C2

Related

ENSDARP00000107011.2, ENSDART00000126853.4
XM_068213203.1 → XP_068069304.1 regulator of G-protein signaling 12b isoform X3