tlr21 toll-like receptor 21 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tlr21provided by ZNC
Official Full Name: toll-like receptor 21provided by ZNC
Primary source: ZFIN:ZDB-GENE-040220-4
See related: Ensembl:ENSDARG00000058045 AllianceGenome:ZFIN:ZDB-GENE-040220-4
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: TLR21.1
Summary: Predicted to enable signaling receptor activity. Acts upstream of or within antibacterial humoral response and toll-like receptor signaling pathway. Located in endoplasmic reticulum. Is expressed in several structures, including gill; heart; integument; liver; and pleuroperitoneal region. [provided by Alliance of Genome Resources, Jan 2025]
Orthologs: all
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Genomic context

Location:: chromosome: 16

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	16	NC_007127.7 (11785898..11789108, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	16	NC_007127.6 (11894996..11898206, complement)

Chromosome 16 - NC_007127.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results suggest that zebTLR9 and zebTLR21 cooperatively mediate the antimicrobial activities of CpG-ODN. Overall, this study provides a molecular basis for the activities of CpG-ODN in fish.
Title: Toll-like receptor 9 and 21 have different ligand recognition profiles and cooperatively mediate activity of CpG-oligodeoxynucleotides in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antibacterial humoral response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pattern recognition receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within toll-like receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: toll-like receptor 21

Names: TIR21.1

NP_001186264.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001199335.1 → NP_001186264.1 toll-like receptor 21 precursor

Status: VALIDATED

Source sequence(s)

BX571826

UniProtKB/TrEMBL

A0A8M1NWC7, F1QMN8

Related

ENSDARP00000098992.3, ENSDART00000060142.6

Conserved Domains (5) summary

smart00255
Location:797 → 942

TIR; Toll - interleukin 1 - resistance

cd00116
Location:336 → 540

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:682 → 694

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:433 → 456

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:84 → 144

LRR_8; Leucine rich repeat