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    Y48G10A.1 S-formylglutathione hydrolase [ Caenorhabditis elegans ]

    Gene ID: 173220, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Y48G10A.1
    Official Full Name
    S-formylglutathione hydrolase
    Primary source
    WormBase:WBGene00013018
    Locus tag
    CELE_Y48G10A.1
    See related
    AllianceGenome:WB:WBGene00013018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable S-formylglutathione hydrolase activity. Predicted to be involved in formaldehyde catabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in intestine; nervous system; and rectal gland cell. Orthologous to human ESD (esterase D). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See Y48G10A.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003279.8 (13489587..13491120)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein NDRG3 Neighboring gene ncRNA Neighboring gene E3 ubiquitin-protein ligase UBR7;RING-type E3 ubiquitin transferase Neighboring gene Protein soem-1 Neighboring gene Peroxisomal coenzyme A diphosphatase ndx-8 Neighboring gene LITAF domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
    2. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article
    3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
    4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables S-formylglutathione hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables S-formylglutathione hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in formaldehyde catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    S-formylglutathione hydrolase
    NP_493371.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13489587..13491120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060970.9 → NP_493371.1  S-formylglutathione hydrolase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EF86
      Conserved Domains (2) summary
      COG0627
      Location:1 → 279
      FrmB; S-formylglutathione hydrolase FrmB [Defense mechanisms]
      cl21494
      Location:1 → 279
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version

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