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    oxsr1a oxidative stress responsive kinase 1a [ Danio rerio (zebrafish) ]

    Gene ID: 568602, updated on 4-Jan-2025

    Summary

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    Official Symbol
    oxsr1aprovided by ZNC
    Official Full Name
    oxidative stress responsive kinase 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070620-25
    See related
    Ensembl:ENSDARG00000034189 AllianceGenome:ZFIN:ZDB-GENE-070620-25
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fb77f12; zgc:165661
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in cellular hyperosmotic response; intracellular signal transduction; and positive regulation of T cell chemotaxis. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytosol. Orthologous to human OXSR1 (oxidative stress responsive kinase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See oxsr1a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (23701659..23721336)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (24046008..24065685)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene ribonuclease P/MRP 40 subunit Neighboring gene chromodomain protein, Y-like Neighboring gene solute carrier family 22 member 13a Neighboring gene xin actin binding repeat containing 1 Neighboring gene uncharacterized LOC110438028

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infection. Hortle E, et al. Life Sci Alliance, 2022 Sep. PMID 35545295, Free PMC Article
    2. Is sodium carboxymethyl cellulose (CMC) really completely innocent? It may be triggering obesity. Baran A, et al. Int J Biol Macromol, 2020 Nov 15. PMID 32987073
    3. Dynamics of Zebrafish Heart Regeneration Using an HPLC-ESI-MS/MS Approach. Ma D, et al. J Proteome Res, 2018 Mar 2. PMID 29369637
    4. WNK1-OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy. Hou CY, et al. Int J Mol Sci, 2022 Oct 11. PMID 36292952, Free PMC Article
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC165661

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular hyperosmotic response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of T cell chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase OSR1a
    Names
    oxidative stress responsive 1a
    NP_001092217.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098747.1 → NP_001092217.1  serine/threonine-protein kinase OSR1a

      See identical proteins and their annotated locations for NP_001092217.1

      Status: PROVISIONAL

      Source sequence(s)
      BC142933
      UniProtKB/TrEMBL
      A0A8M1NDP1, A5PLJ7
      Related
      ENSDARP00000047072.6, ENSDART00000047073.8
      Conserved Domains (2) summary
      smart00220
      Location:17 → 291
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06610
      Location:15 → 291
      STKc_OSR1_SPAK; Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      23701659..23721336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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