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    lig-4 DNA ligase IV [ Caenorhabditis elegans ]

    Gene ID: 176067, updated on 2-Nov-2024

    Summary

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    Official Symbol
    lig-4
    Official Full Name
    DNA ligase IV
    Primary source
    WormBase:WBGene00002986
    Locus tag
    CELE_C07H6.1
    See related
    AllianceGenome:WB:WBGene00002986
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ATP binding activity; DNA binding activity; and DNA ligase (ATP) activity. Involved in DNA repair. Predicted to be located in nucleus. Predicted to be part of DNA ligase IV complex and DNA-dependent protein kinase-DNA ligase 4 complex. Is expressed in head neurons; tail neurons; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including DNA ligase IV deficiency; colorectal cancer; multiple myeloma; pancreatic cancer; and prostate cancer. Orthologous to human LIG4 (DNA ligase 4). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See lig-4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    11
    Sequence:
    Chromosome: III; NC_003281.10 (7521463..7524870)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene E3 ubiquitin-protein ligase PPP1R11 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Homeobox protein lin-39 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Induction and repair of zinc-finger nuclease-targeted double-strand breaks in Caenorhabditis elegans somatic cells. Morton J, et al. Proc Natl Acad Sci U S A, 2006 Oct 31. PMID 17060623, Free PMC Article
    2. Targeted engineering of the Caenorhabditis elegans genome following Mos1-triggered chromosomal breaks. Robert V, et al. EMBO J, 2007 Jan 10. PMID 17159906, Free PMC Article
    3. The 53BP1 homolog in C. elegans influences DNA repair and promotes apoptosis in response to ionizing radiation. Ryu JS, et al. PLoS One, 2013. PMID 23667696, Free PMC Article
    4. Single-strand annealing mediates the conservative repair of double-strand DNA breaks in homologous recombination-defective germ cells of Caenorhabditis elegans. Bae W, et al. DNA Repair (Amst), 2019 Mar. PMID 30710866
    5. Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia. Adamo A, et al. Mol Cell, 2010 Jul 9. PMID 20598602

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA ligase (ATP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA ligase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA ligation involved in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via nonhomologous end joining IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nucleotide-excision repair, DNA gap filling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA ligase IV complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of DNA-dependent protein kinase-DNA ligase 4 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA ligase IV
    NP_001367462.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7521463..7524870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001379799.2 → NP_001367462.1  DNA ligase IV [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95YE6
      Conserved Domains (4) summary
      cd07903
      Location:218 → 451
      Adenylation_DNA_ligase_IV; Adenylation domain of DNA Ligase IV
      pfam04675
      Location:7 → 167
      DNA_ligase_A_N; DNA ligase N-terminus
      cl00038
      Location:644 → 731
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
      cl08424
      Location:459 → 582
      OBF_DNA_ligase_family; The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases
    Nucleotide Protein
    Heading Accession and Version

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