si:dkey-239j18.3 si:dkey-239j18.3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: si:dkey-239j18.3provided by ZNC
Official Full Name: si:dkey-239j18.3provided by ZNC
Primary source: ZFIN:ZDB-GENE-121214-39
See related: Ensembl:ENSDARG00000089806 AllianceGenome:ZFIN:ZDB-GENE-121214-39
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ct; ctsl
Summary: Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to act upstream of or within proteolysis. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L) and CTSV (cathepsin V). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See si:dkey-239j18.3 in Genome Data Viewer

Location:: chromosome: 12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (16634328..16636789, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (16512454..16514992, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

aa605993 (e-PCR)
- UniSTS:186905

ctsl (e-PCR)
- UniSTS:186941

fb37e11.x1 (e-PCR)
- UniSTS:190529

fb30g09.x1 (e-PCR)
- UniSTS:203104

fc87g07.x1 (e-PCR)
- UniSTS:194714

hgg1 (e-PCR)
- UniSTS:238241

fb36g12.x1 (e-PCR)
- UniSTS:187120

Homology

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis involved in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: procathepsin L-like

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

16634328..16636789 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001341678.8 → XP_001341714.2 procathepsin L-like

UniProtKB/TrEMBL

A0A8M1PBG1, A0A8M1Q202, E7F8Y7, P79722

Related

ENSDARP00000110446.1, ENSDART00000128811.3

Conserved Domains (2) summary

smart00848
Location:28 → 86

Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)

pfam00112
Location:115 → 335

Peptidase_C1; Papain family cysteine protease